{"id":"W2950192587","doi":"10.2174/1573406415666190614095821","title":"Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold","year":2020,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Higher Education Commision, Pakistan; Crohn's and Colitis Canada","keywords":"Nucleoside; Nucleotide; Nucleoside triphosphate; Biochemistry; Chemistry; Extracellular; Nucleoside-diphosphate kinase; IC50; Adenosine triphosphate; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001830254,0.0003387955,0.0003438414,0.00002823983,0.0001671353,0.00004258122,0.0001538867,0.0002501942,0.00003415973],"category_scores_gemma":[0.0002468425,0.0003182422,0.00008013901,0.0001953003,0.0002235516,0.00001348877,0.0001385049,0.000263633,0.000002923422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002189114,"about_ca_system_score_gemma":0.00009333606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007356207,"about_ca_topic_score_gemma":0.000001215619,"domain_scores_codex":[0.998314,0.00003317499,0.0003411808,0.0006880761,0.0002489408,0.0003745988],"domain_scores_gemma":[0.9990774,0.00003712609,0.0001384363,0.0001910178,0.0000790948,0.0004769098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003534878,0.00004425892,0.004199815,0.000173151,0.0001112671,0.0001116654,0.0002803492,0.00003333913,0.9870995,0.000006110296,0.005707868,0.001879207],"study_design_scores_gemma":[0.001748528,0.0002314083,0.00103826,0.00007818631,0.000128862,0.0001482878,0.000290261,0.0002638841,0.989544,0.00002328107,0.00611703,0.0003879701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743779,0.02304743,0.0002374408,0.0014913,0.00009096194,0.0001642033,0.0000180415,0.00004741163,0.0005253102],"genre_scores_gemma":[0.9969271,0.0007845783,0.0002872218,0.0009126013,0.0007993213,0.00001961993,0.00008523896,0.00003914436,0.0001451828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02254919,"threshold_uncertainty_score":0.999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007962769240274357,"score_gpt":0.2104557478857081,"score_spread":0.2024929786454337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}