{"id":"W2950192587","doi":"10.2174/1573406415666190614095821","title":"Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold","year":2020,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Higher Education Commision, Pakistan; Crohn's and Colitis Canada","keywords":"Nucleoside; Nucleotide; Nucleoside triphosphate; Biochemistry; Chemistry; Extracellular; Nucleoside-diphosphate kinase; IC50; Adenosine triphosphate; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226566,0.0005704174,0.0003311697,0.0002440554,0.0001093219,0.0001672533,0.0003523017,0.0002836388,0.001254014],"category_scores_gemma":[0.0001003092,0.0001284503,0.0001941537,0.0002024195,0.0001422998,0.0001775922,0.0001479788,0.0005088077,0.0003306977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002709758,"about_ca_system_score_gemma":0.0002253089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008731688,"about_ca_topic_score_gemma":0.002256989,"domain_scores_codex":[0.9999368,0.000009946652,0.000004870692,0.00001472012,0.00001377636,0.00001985328],"domain_scores_gemma":[0.999959,0.000006568327,0.00001192785,0.000003482515,0.000008166234,0.00001077791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007051141,0.0002079929,0.0002838261,0.0003971914,0.00002855658,0.0002973629,0.00003887211,0.0008224577,0.9793963,0.0003863966,0.0008255719,0.01661026],"study_design_scores_gemma":[0.0005314834,0.004532715,0.004385466,0.00005526979,0.0001130013,0.001419837,0.00003977678,0.001703618,0.9578223,0.0001097533,0.02925322,0.00003350723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930047,0.04521183,0.01025886,0.0003580589,0.0002534517,0.0003267556,0.001542317,0.000360013,0.01164179],"genre_scores_gemma":[0.9703655,0.01480452,0.00644575,0.0001663054,0.00002989652,0.0001561109,0.001402027,0.00001666312,0.006613317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254014,"threshold_uncertainty_score":0.004195094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007962769240274357,"score_gpt":0.2104557478857081,"score_spread":0.2024929786454337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}