{"id":"W2950199047","doi":"10.1021/jm000020b","title":"Novel Inhibitors of Nucleoside Triphosphate Diphosphohydrolases:  Chemical Synthesis and Biochemical and Pharmacological Characterizations","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Nucleoside triphosphate; Purinergic receptor; Nucleoside; Nucleotide; Purine; Enzyme; Biochemistry; Receptor; Adenosine triphosphate; Adenine nucleotide; ATP hydrolysis; Stereochemistry; ATPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034466,0.000658272,0.0004968861,0.0002352816,0.0001553041,0.0003433123,0.0004004118,0.0003709887,0.001306048],"category_scores_gemma":[0.0001884255,0.0001959239,0.000225368,0.0002303323,0.0001619959,0.0003370187,0.0001526652,0.0006941996,0.0006088237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549197,"about_ca_system_score_gemma":0.0002654018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002981003,"about_ca_topic_score_gemma":0.0007034256,"domain_scores_codex":[0.999907,0.00001107712,0.00001207965,0.00002066378,0.00002677264,0.00002237876],"domain_scores_gemma":[0.9998896,0.00002364473,0.00002697672,0.00001080243,0.0000190584,0.00002986979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000178978,0.0001205769,0.00005303446,0.0002548659,0.00001380979,0.000144957,0.00001809628,0.0004536582,0.987716,0.0004374536,0.00009599893,0.0105126],"study_design_scores_gemma":[0.00008718391,0.0009363389,0.0005578704,0.0000134759,0.00004170539,0.0004882292,0.000008728121,0.0008071142,0.9821705,0.00009276167,0.01478479,0.00001141608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7919583,0.09204846,0.09617485,0.0005150943,0.000393814,0.001424713,0.002706738,0.0005832276,0.01419483],"genre_scores_gemma":[0.880066,0.04677462,0.06091281,0.0002147042,0.0001582914,0.0008781589,0.002384929,0.0000606247,0.00854978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306048,"threshold_uncertainty_score":0.004369199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006821152891889875,"score_gpt":0.2324019012915933,"score_spread":0.2255807483997034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}