{"id":"W2950207837","doi":"10.1136/annrheumdis-2019-eular.8657","title":"LB0004 METHOTREXATE WITHDRAWAL IN PATIENTS WITH RHEUMATOID ARTHRITIS WHO ACHIEVE LOW DISEASE ACTIVITY WITH TOFACITINIB MODIFIED-RELEASE 11 MG ONCE DAILY + METHOTREXATE: A RANDOMISED NON-INFERIORITY PHASE 3B/4 STUDY","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Montreal Clinical Research Institute; Western University","funders":"","keywords":"Tofacitinib; Medicine; Rheumatoid arthritis; Methotrexate; Clinical endpoint; Internal medicine; Placebo; Phases of clinical research; Gastroenterology; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001700222,0.00215644,0.003747845,0.0006097156,0.0004878831,0.001533319,0.001084967,0.002068966,0.01226839],"category_scores_gemma":[0.001654768,0.0008192288,0.003249448,0.0005311876,0.001572834,0.001319476,0.000552751,0.003983106,0.002064258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009104026,"about_ca_system_score_gemma":0.0009802614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353771,"about_ca_topic_score_gemma":0.002338582,"domain_scores_codex":[0.99925,0.0003864489,0.00004731082,0.00009958164,0.00005557834,0.0001610679],"domain_scores_gemma":[0.9991842,0.0002437417,0.0001638776,0.00007748373,0.00004188609,0.0002887143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9659466,0.005240328,0.0004663587,0.0006207881,0.0009215152,0.00007095514,0.00004961462,0.0003143906,0.004599616,0.0001190411,0.0009378704,0.02071276],"study_design_scores_gemma":[0.9512436,0.04629697,0.001276575,0.00002273108,0.0002682656,0.00002978859,0.00001354131,0.0001859876,0.0001826782,0.00007775737,0.0003890079,0.00001311219],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825865,0.006549482,0.0009999725,0.00103073,0.0007388933,0.002649714,0.001368961,0.0003418076,0.003733956],"genre_scores_gemma":[0.9833887,0.00293114,0.001535983,0.001625885,0.0007314117,0.002799777,0.001690982,0.00006444306,0.00523174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226839,"threshold_uncertainty_score":0.04104185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531207139251734,"score_gpt":0.2951889365168673,"score_spread":0.2798768651243499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}