{"id":"W2950210042","doi":"10.1002/hon.119_2630","title":"MANAGING CYTOKINE RELEASE SYNDROME (CRS) AND NEUROTOXICITY WITH STEP‐UP DOSING OF MOSUNETUZUMAB IN RELAPSED/REFRACTORY (R/R) B‐CELL NON‐HODGKIN LYMPHOMA (NHL)","year":2019,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; Jewish General Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Dosing; Cytokine release syndrome; Adverse effect; Gastroenterology; Chills; Internal medicine; Refractory (planetary science); Toxicity; Lymphoma; Neurotoxicity; Anesthesia; Immunotherapy; Cancer; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003316246,0.0002299899,0.0003514237,0.0001451475,0.000131376,0.0001841696,0.0002637481,0.0001704442,0.0006871377],"category_scores_gemma":[0.0004147798,0.0000729614,0.0001769895,0.0001167324,0.0001150169,0.0001822578,0.0001391556,0.0005175805,0.00015048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466316,"about_ca_system_score_gemma":0.0002281053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003023781,"about_ca_topic_score_gemma":0.001154574,"domain_scores_codex":[0.9999173,0.00002633043,0.000009572148,0.00001055345,0.00002140751,0.00001485329],"domain_scores_gemma":[0.999869,0.000033787,0.00005249197,0.00001189452,0.00001194081,0.00002096858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01482101,0.004878824,0.05144102,0.0008020889,0.0003868077,0.001100776,0.0003019064,0.003703868,0.1474701,0.0001291149,0.002310493,0.772654],"study_design_scores_gemma":[0.01868344,0.2659216,0.5279108,0.0003646642,0.0009510884,0.01405944,0.0002266666,0.01001865,0.1450713,0.0005296821,0.01620547,0.0000572175],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967659,0.001838983,0.0004288643,0.00005603231,0.000006089211,0.0001293698,0.00006294429,0.00003545864,0.0006765077],"genre_scores_gemma":[0.9979339,0.0008449475,0.0006791426,0.00006970793,0.00001341803,0.00006073184,0.0001192178,0.000003819954,0.0002751806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006871377,"threshold_uncertainty_score":0.002298772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171576477668178,"score_gpt":0.2974048794280057,"score_spread":0.2756891146513239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}