{"id":"W2950210042","doi":"10.1002/hon.119_2630","title":"MANAGING CYTOKINE RELEASE SYNDROME (CRS) AND NEUROTOXICITY WITH STEP‐UP DOSING OF MOSUNETUZUMAB IN RELAPSED/REFRACTORY (R/R) B‐CELL NON‐HODGKIN LYMPHOMA (NHL)","year":2019,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; Jewish General Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Dosing; Cytokine release syndrome; Adverse effect; Gastroenterology; Chills; Internal medicine; Refractory (planetary science); Toxicity; Lymphoma; Neurotoxicity; Anesthesia; Immunotherapy; Cancer; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005556806,0.0003198997,0.00138945,0.0003446046,0.00004989278,0.00001322649,0.0002113967,0.000441336,0.001134361],"category_scores_gemma":[0.0001264226,0.0002398691,0.0001058017,0.0005001218,0.000413926,0.0000785731,0.0002265347,0.0006581138,0.00006194666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003802103,"about_ca_system_score_gemma":0.0002951338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001592853,"about_ca_topic_score_gemma":0.0000477838,"domain_scores_codex":[0.997152,0.0003467184,0.0006628627,0.0007160889,0.0004533451,0.0006689559],"domain_scores_gemma":[0.9979835,0.0008085261,0.0002595316,0.0005633496,0.00009918211,0.0002859196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02913031,0.005345892,0.3195799,0.003075826,0.000234524,0.02595372,0.0008722862,0.0001195703,0.5467504,0.0009212164,0.000434567,0.06758181],"study_design_scores_gemma":[0.1342648,0.09467867,0.5313249,0.002845372,0.0005350563,0.05669938,0.002930642,0.02975562,0.1110355,0.001421548,0.0318861,0.002622405],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877921,0.0003565152,0.0001026781,0.0006676169,0.0001087851,0.001440927,0.000004508533,0.00006319625,0.009463629],"genre_scores_gemma":[0.9965248,0.0002505818,0.000995503,0.0005046201,0.00002251019,0.00006197333,0.000009011689,0.00004762178,0.001583456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4357149,"threshold_uncertainty_score":0.9997787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171576477668178,"score_gpt":0.2974048794280057,"score_spread":0.2756891146513239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}