{"id":"W2950212682","doi":"10.1055/s-2001-10788","title":"Reductive Alkylation of γ-Cyano-α,β-unsaturated Ketones. A Modified Robinson Annulation Process to α,α-Disubstituted β,γ-unsaturated Cyclohexanone System","year":2001,"lang":"en","type":"article","venue":"Synlett","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Science Council","keywords":"Chemistry; Annulation; Cyclohexanone; Alkylation; Regioselectivity; Cyclohexenone; Organic chemistry; Ketone; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735549,0.0003909093,0.0001490731,0.0001892782,0.0001285535,0.0001284089,0.0001985648,0.000142149,0.001754823],"category_scores_gemma":[0.0001386234,0.0001284411,0.0001544601,0.0001603868,0.0002010364,0.0003112158,0.0002344649,0.0003705996,0.0006212152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871134,"about_ca_system_score_gemma":0.0002910791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004739207,"about_ca_topic_score_gemma":0.001397054,"domain_scores_codex":[0.9999105,0.00001493073,0.00001067689,0.00001817972,0.00001680402,0.00002890284],"domain_scores_gemma":[0.999947,0.000007191375,0.00001624758,0.000008330882,0.000009799539,0.0000115496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000104575,0.00001530379,0.000146538,0.0001181718,0.00001160268,0.0002468602,0.00009850843,0.0002677377,0.992504,0.001015199,0.00008334145,0.005388063],"study_design_scores_gemma":[0.00001316058,0.0002346053,0.000659515,0.000006723308,0.00001090871,0.0003287938,0.00003094256,0.0002363407,0.9932148,0.0001109212,0.005141597,0.00001168257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536731,0.003725522,0.01989178,0.0002209773,0.0001252468,0.0001298621,0.0004068308,0.0002046979,0.02162183],"genre_scores_gemma":[0.9870243,0.002285457,0.004969804,0.00007057537,0.00001269395,0.0000327833,0.0003024458,0.00002095132,0.005281054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001754823,"threshold_uncertainty_score":0.005870461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008925109858296617,"score_gpt":0.2547855468203549,"score_spread":0.2458604369620583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}