{"id":"W2950235287","doi":"10.1038/onc.2014.279","title":"Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis","year":2014,"lang":"en","type":"article","venue":"Oncogene","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Toronto General Hospital; University of Toronto; Toronto Centre for Phenogenomics; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Cure Brain Cancer Foundation; Canadian Institutes of Health Research; Hospital for Sick Children; Terry Fox Foundation; Canadian Breast Cancer Research Alliance","keywords":"Biology; Wnt signaling pathway; Transdifferentiation; Carcinogenesis; GSK-3; Mammary gland; Cancer research; Catenin; Mammary tumor; Glycogen synthase; Endocrinology; Internal medicine; Epithelium; Cell biology; Signal transduction; Stem cell; Glycogen; Cancer; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003192346,0.0005524734,0.0002966645,0.0009536589,0.0002088457,0.0004637542,0.0003327204,0.0006392816,0.001995512],"category_scores_gemma":[0.0002022093,0.0003555081,0.0005511984,0.0002819892,0.0004771388,0.000275512,0.000351044,0.0009514264,0.0005688428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006366055,"about_ca_system_score_gemma":0.0004977232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0012585,"about_ca_topic_score_gemma":0.001911769,"domain_scores_codex":[0.9996217,0.00007304145,0.00004677114,0.00007326694,0.00009203765,0.00009321533],"domain_scores_gemma":[0.9996495,0.00006926983,0.0001068392,0.00005415421,0.00001747372,0.0001025859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002961021,0.00006563078,0.0002865815,0.00001978319,0.000009732064,0.0001205139,0.00001830921,0.00009255953,0.9978244,0.000230713,0.00004691015,0.0009887584],"study_design_scores_gemma":[0.00004915909,0.0004226346,0.003037484,0.000009630101,0.0000262085,0.0002920915,0.00002523803,0.0007109431,0.9928432,0.0001334431,0.002442405,0.000007737473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915884,0.002328926,0.001852166,0.0002271715,0.00006549842,0.0000761046,0.001020355,0.000292753,0.002548703],"genre_scores_gemma":[0.9904206,0.001197044,0.001583512,0.0001040394,0.0000103319,0.00007962579,0.00107487,0.0000845671,0.005445274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001995512,"threshold_uncertainty_score":0.006675601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00599498261389853,"score_gpt":0.2322850316280551,"score_spread":0.2262900490141566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}