{"id":"W2950235287","doi":"10.1038/onc.2014.279","title":"Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis","year":2014,"lang":"en","type":"article","venue":"Oncogene","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Toronto General Hospital; University of Toronto; Toronto Centre for Phenogenomics; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Cure Brain Cancer Foundation; Canadian Institutes of Health Research; Hospital for Sick Children; Terry Fox Foundation; Canadian Breast Cancer Research Alliance","keywords":"Biology; Wnt signaling pathway; Transdifferentiation; Carcinogenesis; GSK-3; Mammary gland; Cancer research; Catenin; Mammary tumor; Glycogen synthase; Endocrinology; Internal medicine; Epithelium; Cell biology; Signal transduction; Stem cell; Glycogen; Cancer; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004178739,0.0001903928,0.000203274,0.00006324922,0.00007706974,0.00001429984,0.0001369038,0.0001358517,0.00001058732],"category_scores_gemma":[0.00007302158,0.000164807,0.00004663059,0.00007885087,0.00004195179,0.000004849696,0.00008759184,0.00004493676,0.000007029753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003162313,"about_ca_system_score_gemma":0.00007657296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009925529,"about_ca_topic_score_gemma":0.000007036785,"domain_scores_codex":[0.9990041,0.0001062171,0.0002153764,0.0003278221,0.0001679763,0.0001785084],"domain_scores_gemma":[0.9994647,0.00005073447,0.0001078742,0.0002429713,0.00005525402,0.0000784466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003893603,0.00004185228,0.002167557,0.00006353457,0.00007378893,0.000001870987,0.0000445021,0.00002127959,0.9046029,0.0000264429,0.0003342301,0.09223262],"study_design_scores_gemma":[0.0009078659,0.000739608,0.0005292883,0.00003334134,0.0000217811,0.00000470221,0.000005616493,0.00002006724,0.9674051,0.000006398876,0.03012775,0.0001984366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965932,0.0004143329,0.00146921,0.00003410637,0.00008767079,0.000165261,0.000005782582,0.00001460911,0.001215875],"genre_scores_gemma":[0.9970711,0.0001147824,0.001668908,0.0001128649,0.0001229124,0.00005225126,0.0001249746,0.00002495617,0.0007072227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09203418,"threshold_uncertainty_score":0.6720635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00599498261389853,"score_gpt":0.2322850316280551,"score_spread":0.2262900490141566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}