{"id":"W2950251856","doi":"10.1016/j.parkreldis.2019.05.002","title":"Genome-wide estimates of heritability and genetic correlations in essential tremor","year":2019,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute on Aging; U.S. Department of Health and Human Services; National Institutes of Health; Ministerio de Ciencia e Innovación; National Institute of Neurological Disorders and Stroke","keywords":"Heritability; Biology; Missing heritability problem; Linkage disequilibrium; Genetic architecture; Genetics; Genome-wide association study; Genetic correlation; Disease; Explained variation; Genetic variation; Quantitative trait locus; Medicine; Genotype; Statistics; Genetic variants; Internal medicine; Single-nucleotide polymorphism; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002156145,0.0005845432,0.00056441,0.00150563,0.0004152887,0.0007276796,0.0005055937,0.0007893254,0.002640348],"category_scores_gemma":[0.006054884,0.0004678763,0.001073009,0.001363353,0.0004531535,0.0004791835,0.0007211593,0.0007083569,0.000293553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142586,"about_ca_system_score_gemma":0.0001765875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005195068,"about_ca_topic_score_gemma":0.004591123,"domain_scores_codex":[0.9980868,0.0007677248,0.0001664364,0.0006342603,0.0001939852,0.0001508897],"domain_scores_gemma":[0.9954274,0.002807506,0.0008554893,0.0005184964,0.0002345602,0.0001565871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005957653,0.00006400874,0.9814005,0.00004825177,0.002567007,0.0006330698,0.000369304,0.001196505,0.005057529,0.0004399203,0.0004376796,0.007190457],"study_design_scores_gemma":[0.0000156857,0.00002863964,0.998049,0.000009099596,0.0002838552,0.0003162046,0.00006790813,0.000618147,0.0001633989,0.0002859489,0.0001547226,0.000007355624],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994375,0.001188424,0.001737914,0.000213315,0.00002031703,0.000007868039,0.001482579,0.00004893604,0.0009257523],"genre_scores_gemma":[0.9986406,0.00017402,0.0003743405,0.00002323245,0.00001623697,0.000004287824,0.0005996124,0.00001196696,0.0001558242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005195068,"threshold_uncertainty_score":0.0114029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880444911468314,"score_gpt":0.2321484989542028,"score_spread":0.2262680540427345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}