{"id":"W2950252509","doi":"10.1128/mbio.01113-19","title":"Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Servier; Wellcome Trust; National Institutes of Health; amfAR, The Foundation for AIDS Research","keywords":"Downregulation and upregulation; Tetherin; Cell; Cell biology; Interferon; Intracellular; Biology; Cell culture; Virology; Chemistry; Viral replication; Virus; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001377489,0.0001011016,0.0001769894,0.0000655591,0.0000491949,0.000006542289,0.0001387627,0.0001388916,0.002387963],"category_scores_gemma":[0.00006112852,0.00007503742,0.00006166071,0.000124531,0.00007540589,0.00006208074,0.00004469147,0.0001744832,0.001097273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002759424,"about_ca_system_score_gemma":0.00002580264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004976902,"about_ca_topic_score_gemma":0.00001027875,"domain_scores_codex":[0.9991646,0.0002645654,0.0002567855,0.0001646892,0.00002978903,0.0001195258],"domain_scores_gemma":[0.9992545,0.000165916,0.0001730991,0.000282954,0.0001147829,0.000008713643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001005517,0.00008727342,0.0004183,0.00001222992,0.00004551748,3.088877e-8,0.0007649566,0.00001010926,0.9727646,0.000009858821,0.0246122,0.000269478],"study_design_scores_gemma":[0.0003604362,0.0004312068,0.003764764,0.00004090088,0.00001993059,0.000001115148,0.0002540384,0.000006190167,0.9567365,0.00001019537,0.03829953,0.00007516534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959024,0.0002166413,0.0001213969,0.0001696992,0.001958071,0.0004096217,0.00004361208,0.00002569048,0.001152928],"genre_scores_gemma":[0.9796514,0.00001000257,0.00003019172,0.00005752011,0.0000112576,0.000008034252,0.0001030297,0.000009125124,0.02011942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01896649,"threshold_uncertainty_score":0.9996805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168855154236662,"score_gpt":0.2135641097122229,"score_spread":0.2018755581698563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}