{"id":"W2950254307","doi":"10.3389/fmicb.2019.01499","title":"The Response of Cupriavidus metallidurans CH34 to Cadmium Involves Inhibition of the Initiation of Biofilm Formation, Decrease in Intracellular c-di-GMP Levels, and a Novel Metal Regulated Phosphodiesterase","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Comisión Nacional de Investigación Científica y Tecnológica; Ministerio de Educación, Gobierno de Chile; Universidad Técnica Federico Santa María","keywords":"Intracellular; Biofilm; Microbiology; Chemistry; Stringent response; Phosphodiesterase; Cadmium; Biology; Bacteria; Biochemistry; Enzyme; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001202107,0.0001024277,0.000285088,0.0001332928,0.00004631125,0.000009838022,0.0001843699,0.00008865847,0.00001633787],"category_scores_gemma":[0.0003274425,0.00006888435,0.00004412736,0.0003591086,0.0002592742,0.0001260785,0.00007927812,0.00006172039,0.000002276832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004507851,"about_ca_system_score_gemma":0.0000794619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062839,"about_ca_topic_score_gemma":0.00009739117,"domain_scores_codex":[0.9986539,0.0003240223,0.0006135215,0.0001806081,0.00005995819,0.0001679599],"domain_scores_gemma":[0.9990545,0.0001998198,0.000329904,0.0002912434,0.00009374242,0.00003077712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004236128,0.00008929634,0.004419661,0.00002540404,0.00000898362,2.01596e-7,0.0009289955,0.00008330963,0.9934899,0.000384168,0.00005566561,0.00009076844],"study_design_scores_gemma":[0.0005998254,0.00005226746,0.01907118,0.00007591532,0.0000193482,0.000005409885,0.0006077053,0.0001902034,0.9788617,0.000255853,0.0001883385,0.00007222177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965184,0.0004260839,0.001614761,0.0005208684,0.0001559155,0.000584561,0.0001705711,0.000004853754,0.000003999626],"genre_scores_gemma":[0.9970876,0.00002175582,0.002767885,0.00004786407,0.000003824692,0.00003301015,0.00001244679,0.000006703622,0.000018889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01465152,"threshold_uncertainty_score":0.2809022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183450923147872,"score_gpt":0.2165245182061306,"score_spread":0.2046900089746519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}