{"id":"W2950254307","doi":"10.3389/fmicb.2019.01499","title":"The Response of Cupriavidus metallidurans CH34 to Cadmium Involves Inhibition of the Initiation of Biofilm Formation, Decrease in Intracellular c-di-GMP Levels, and a Novel Metal Regulated Phosphodiesterase","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Comisión Nacional de Investigación Científica y Tecnológica; Ministerio de Educación, Gobierno de Chile; Universidad Técnica Federico Santa María","keywords":"Intracellular; Biofilm; Microbiology; Chemistry; Stringent response; Phosphodiesterase; Cadmium; Biology; Bacteria; Biochemistry; Enzyme; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159165,0.0007275295,0.0003625488,0.0002880275,0.0001886039,0.0002124814,0.0002840371,0.0003569315,0.0006673157],"category_scores_gemma":[0.0002106544,0.0001540365,0.0003468756,0.0002650031,0.0001670934,0.0001483867,0.0003262557,0.0003792542,0.0001625567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002484591,"about_ca_system_score_gemma":0.0002041956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094545,"about_ca_topic_score_gemma":0.002080036,"domain_scores_codex":[0.9998479,0.0000157203,0.00001535245,0.00003857558,0.00005045047,0.0000319937],"domain_scores_gemma":[0.999882,0.00001998484,0.00003681216,0.00001464745,0.00002483944,0.0000217234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003587767,0.00001245202,0.0002567792,0.00002766923,0.000002152104,0.00002843329,0.000008758651,0.00002705912,0.9991298,0.000009562859,0.00001537883,0.0004460531],"study_design_scores_gemma":[0.00001939902,0.0009360131,0.04759475,0.000009997097,0.00003090744,0.0004599303,0.0001117528,0.0008055394,0.9483337,0.00006250176,0.001614929,0.00002055213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972474,0.0003641887,0.0008660603,0.00007347912,0.00001205843,0.00003784845,0.0008568566,0.00006147044,0.0004806495],"genre_scores_gemma":[0.9933334,0.0002896509,0.002818816,0.00005121308,0.000006613155,0.00005407374,0.001849235,0.00001565199,0.001581444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094545,"threshold_uncertainty_score":0.004164755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183450923147872,"score_gpt":0.2165245182061306,"score_spread":0.2046900089746519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}