{"id":"W2950270989","doi":"10.3233/blc-190218","title":"Molecular Biomarkers of Response to PD-1/ PD-L1 Immune Checkpoint Blockade in Advanced Bladder Cancer","year":2019,"lang":"en","type":"review","venue":"Bladder Cancer","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute","keywords":"Medicine; Oncology; Internal medicine; Bladder cancer; PD-L1; Meta-analysis; Immunotherapy; Blockade; Clinical trial; Disease; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0005597577,0.001385191,0.004583901,0.001108418,0.00006328594,0.00003424447,0.0006316558,0.0007949487,0.002305022],"category_scores_gemma":[0.0001740828,0.001165385,0.001466473,0.001846799,0.0001858117,0.0001285383,0.0002841243,0.0008524391,0.0002241267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001804625,"about_ca_system_score_gemma":0.004639741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002937153,"about_ca_topic_score_gemma":0.0003338682,"domain_scores_codex":[0.9936876,0.0004358946,0.002043808,0.001622893,0.001003777,0.001206074],"domain_scores_gemma":[0.9963136,0.0002220858,0.0008290123,0.001820878,0.0003038735,0.0005105694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009157984,0.0008537326,0.0003395315,0.02173097,0.0085933,0.0004979951,0.0008490017,0.0001610895,0.008346513,0.00001156482,0.001945986,0.9475123],"study_design_scores_gemma":[0.006531715,0.0008077479,0.001680085,0.03237378,0.005622046,0.00006427098,0.0001263622,0.00000911114,0.006050562,0.00001411275,0.9453644,0.001355798],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005365829,0.9842561,0.00002081212,0.0008751948,0.001272179,0.005618832,0.0008441251,0.00009214389,0.001654764],"genre_scores_gemma":[0.002559282,0.9875316,0.0003436906,0.0006306506,0.000305528,0.003646078,0.0001286016,0.0004150367,0.004439519],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9461566,"threshold_uncertainty_score":0.9998899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03949301475115467,"score_gpt":0.3752436445870284,"score_spread":0.3357506298358737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}