{"id":"W2950270989","doi":"10.3233/blc-190218","title":"Molecular Biomarkers of Response to PD-1/ PD-L1 Immune Checkpoint Blockade in Advanced Bladder Cancer","year":2019,"lang":"en","type":"review","venue":"Bladder Cancer","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute","keywords":"Medicine; Oncology; Internal medicine; Bladder cancer; PD-L1; Meta-analysis; Immunotherapy; Blockade; Clinical trial; Disease; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00694323,0.001062195,0.007311937,0.009399225,0.000378863,0.002245664,0.001216665,0.001914084,0.003508874],"category_scores_gemma":[0.02630306,0.0006015633,0.00556975,0.01041783,0.000688135,0.001629462,0.0008066461,0.0009595261,0.0002917411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002682614,"about_ca_system_score_gemma":0.005387342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00407223,"about_ca_topic_score_gemma":0.008730689,"domain_scores_codex":[0.9954118,0.001591344,0.001728501,0.0004253837,0.0007130775,0.0001299237],"domain_scores_gemma":[0.9775768,0.01532552,0.005267822,0.0001828312,0.001521613,0.0001254065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006788265,0.00003907847,0.00224015,0.9168536,0.01078748,0.0001162024,0.0001042297,0.0001260997,0.0003024144,0.0002219923,0.001172796,0.06735712],"study_design_scores_gemma":[0.001014442,0.001110341,0.02073295,0.7957388,0.1535129,0.0008010835,0.000320896,0.0002476836,0.0006915373,0.0006284298,0.02511444,0.00008662136],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001057157,0.9983443,0.00004360935,0.0001156294,0.00004001647,0.00008193856,0.0001519859,0.000002219272,0.000163172],"genre_scores_gemma":[0.02492924,0.973125,0.0005188353,0.0005102098,0.0001138572,0.0004307566,0.0002428791,0.000003322294,0.000125933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009399225,"threshold_uncertainty_score":0.03671974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03949301475115467,"score_gpt":0.3752436445870284,"score_spread":0.3357506298358737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}