{"id":"W2950341634","doi":"10.1002/chin.200312169","title":"Design and Synthesis of 6‐Substituted Amino‐4‐oxa‐1‐azabicyclo[3,2,0]heptan‐7‐one Derivatives as Cysteine Proteases Inhibitors.","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Syncrude (Canada)","funders":"","keywords":"Chemistry; Proteases; Cysteine; Stereochemistry; Combinatorial chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181985,0.0005225276,0.0005188084,0.0002550417,0.0001920013,0.0003761642,0.0006184266,0.0003523044,0.002989693],"category_scores_gemma":[0.0001565686,0.0002979857,0.0002369685,0.0002710409,0.0001942948,0.0002561578,0.000187983,0.0006411176,0.001194055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004430652,"about_ca_system_score_gemma":0.0004934105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007293438,"about_ca_topic_score_gemma":0.001847166,"domain_scores_codex":[0.9998826,0.0000221606,0.00001104592,0.00001828355,0.00002562416,0.0000402609],"domain_scores_gemma":[0.999956,0.000003594858,0.00001006905,0.000004028077,0.000009000443,0.00001729106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008781738,0.0003175442,0.0001389102,0.0005748836,0.00004678147,0.0004331672,0.0001091349,0.002872078,0.9519252,0.003174653,0.001546041,0.03798334],"study_design_scores_gemma":[0.0005193754,0.002482117,0.0007687567,0.0000423499,0.00007427708,0.0005372656,0.00003380569,0.002276055,0.9533511,0.000377417,0.03949178,0.00004561372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.875092,0.03258837,0.04141465,0.001079742,0.0009955682,0.001795845,0.002675995,0.0008380304,0.04351981],"genre_scores_gemma":[0.9355839,0.01538318,0.0287085,0.0002736421,0.00008594991,0.0004429594,0.001872007,0.00007763935,0.01757213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002989693,"threshold_uncertainty_score":0.01000148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012139301415027,"score_gpt":0.2491070419390848,"score_spread":0.2289856489249345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}