{"id":"W2950359183","doi":"10.1073/pnas.1818210116","title":"Cancer stemness, intratumoral heterogeneity, and immune response across cancers","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":607,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Children's Hospital; University of British Columbia","funders":"Canadian Cancer Society","keywords":"Immune system; Cancer; Biology; Cancer research; Medicine; Oncology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004069618,0.00008626899,0.0002263096,0.0009719942,0.0001364587,0.0004176371,0.00008700792,0.0001390351,0.0005870236],"category_scores_gemma":[0.0006721174,0.00006054778,0.00008075258,0.0005236474,0.0002997126,0.0002611191,0.0003096971,0.0002624147,0.000075816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867566,"about_ca_system_score_gemma":0.0001233458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002665066,"about_ca_topic_score_gemma":0.0005297697,"domain_scores_codex":[0.9997696,0.0000524816,0.00001939247,0.00005580924,0.00006924784,0.00003338996],"domain_scores_gemma":[0.999445,0.0001551683,0.0002250886,0.00003998448,0.0000655869,0.00006924682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005398343,0.00006436315,0.5346759,0.00009398325,0.0001510576,0.0001322818,0.000236534,0.0009876435,0.4407685,0.0004764055,0.0001194503,0.02175412],"study_design_scores_gemma":[0.000006254578,0.0002596812,0.9616998,0.000007297226,0.00006136567,0.0004981988,0.0002845311,0.001782031,0.03398744,0.0005557963,0.0008512694,0.000006356794],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998178,0.0006244112,0.0007254914,0.00002621641,0.000001538535,0.000006565288,0.0001154271,0.00001066518,0.0003116788],"genre_scores_gemma":[0.999539,0.00009299345,0.0001769058,0.00001651664,0.000002739432,0.00000509011,0.00009752854,0.000002507887,0.00006674092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009719942,"threshold_uncertainty_score":0.002152264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03707180813737486,"score_gpt":0.3530025006146993,"score_spread":0.3159306924773245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}