{"id":"W2950359233","doi":"10.3324/haematol.2019.217448","title":"Daratumumab-based regimens are highly effective and well tolerated in relapsed or refractory multiple myeloma regardless of patient age: subgroup analysis of the phase 3 CASTOR and POLLUX studies","year":2019,"lang":"en","type":"article","venue":"Haematologica","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Daratumumab; Dexamethasone; Medicine; Lenalidomide; Internal medicine; Hazard ratio; Neutropenia; Bortezomib; Multiple myeloma; Progression-free survival; Confidence interval; Oncology; Gastroenterology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004484,0.0002303302,0.001242706,0.0003481388,0.00007636758,0.000007780452,0.00008297532,0.0001274061,0.00004672183],"category_scores_gemma":[0.0007460779,0.0001226162,0.0001278238,0.0008194124,0.0003446102,0.00003791389,0.0001046059,0.0002028444,0.000002751246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000983599,"about_ca_system_score_gemma":0.00005726762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002067742,"about_ca_topic_score_gemma":0.0007474688,"domain_scores_codex":[0.9981757,0.0003550907,0.0004452234,0.0004199273,0.0003319986,0.0002720235],"domain_scores_gemma":[0.9980096,0.0008138458,0.0003750857,0.0004832076,0.0002046723,0.0001135646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01416952,0.001958462,0.9628875,0.001004438,0.002783551,0.001725798,0.002218951,0.00004087749,0.009681999,0.00003521852,0.0001476193,0.003346045],"study_design_scores_gemma":[0.02026547,0.003741424,0.9359077,0.0007854229,0.0009024153,0.00004482837,0.002637705,0.003609418,0.03174491,0.000009859627,0.000152939,0.0001979651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964287,0.001563941,0.000001369704,0.0001806213,0.00004592891,0.00157569,0.00006744212,0.0000182469,0.0001180992],"genre_scores_gemma":[0.9993951,0.00009145527,0.0001864047,0.00005489819,0.000003645013,0.00008752567,0.00002723389,0.00001304625,0.000140639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02697988,"threshold_uncertainty_score":0.5000144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860394486689076,"score_gpt":0.3202406490927045,"score_spread":0.2916367042258137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}