{"id":"W2950359233","doi":"10.3324/haematol.2019.217448","title":"Daratumumab-based regimens are highly effective and well tolerated in relapsed or refractory multiple myeloma regardless of patient age: subgroup analysis of the phase 3 CASTOR and POLLUX studies","year":2019,"lang":"en","type":"article","venue":"Haematologica","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Daratumumab; Dexamethasone; Medicine; Lenalidomide; Internal medicine; Hazard ratio; Neutropenia; Bortezomib; Multiple myeloma; Progression-free survival; Confidence interval; Oncology; Gastroenterology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003307434,0.0006117929,0.00259263,0.0007537331,0.0002675076,0.0008811645,0.0003140212,0.0004618812,0.001133433],"category_scores_gemma":[0.002659014,0.0002707379,0.004190245,0.001047029,0.0001989573,0.0004560737,0.0003776705,0.0006881944,0.0001510154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003876745,"about_ca_system_score_gemma":0.0003938757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005258129,"about_ca_topic_score_gemma":0.001926717,"domain_scores_codex":[0.9982325,0.0008548597,0.0002675651,0.0001778968,0.0002611818,0.0002060719],"domain_scores_gemma":[0.9985233,0.0005692417,0.0004553482,0.0001820581,0.0001011523,0.0001689666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4283786,0.001221705,0.3163183,0.002254148,0.06819534,0.0009386447,0.0003227361,0.001759316,0.01567393,0.0002575436,0.003380938,0.1612988],"study_design_scores_gemma":[0.04898142,0.03146794,0.8650514,0.0002812437,0.03664521,0.001732227,0.0003339607,0.00160549,0.00302001,0.0006585895,0.01012845,0.00009408777],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975013,0.02180252,0.000319097,0.0001907504,0.00007304159,0.0003148902,0.001028648,0.0000214949,0.001236745],"genre_scores_gemma":[0.9966508,0.001834846,0.0001525091,0.000148102,0.00006701592,0.0001024398,0.0008155055,0.000007834817,0.0002209716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003307434,"threshold_uncertainty_score":0.01749158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860394486689076,"score_gpt":0.3202406490927045,"score_spread":0.2916367042258137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}