{"id":"W2950360708","doi":"10.1016/j.bmcl.2006.05.005","title":"Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Acetylation; Histone deacetylase; Chemistry; Histone; In vitro; Cell growth; Cancer cell; HDAC11; Histone deacetylase 5; Enzyme; Cancer research; HDAC1; Cell cycle; Biochemistry; Cancer; Apoptosis; Biology; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086353,0.0003482319,0.0002893655,0.0002244489,0.0001607909,0.000248148,0.000498572,0.0003230273,0.002252552],"category_scores_gemma":[0.0001617599,0.0001754902,0.0001438316,0.0001797973,0.0002275559,0.0003504972,0.0001804339,0.0004957585,0.0007159358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768459,"about_ca_system_score_gemma":0.0002363928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003837954,"about_ca_topic_score_gemma":0.0008233633,"domain_scores_codex":[0.9998829,0.00002622877,0.000008345299,0.00001910648,0.0000293493,0.00003399173],"domain_scores_gemma":[0.9999282,0.00001115735,0.00002540129,0.000005683707,0.000009809642,0.00001974123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005606656,0.0001635258,0.00009512812,0.0002922051,0.00001630923,0.000265013,0.00005790229,0.000797987,0.967431,0.003896706,0.0008694489,0.02555401],"study_design_scores_gemma":[0.000303959,0.00288785,0.001947514,0.00003286541,0.00004023507,0.001013253,0.00004107703,0.001910227,0.9464757,0.0004884272,0.04481851,0.000040318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8393166,0.06932953,0.03558499,0.0009600683,0.0008502035,0.0003248422,0.0006745683,0.0009630866,0.05199607],"genre_scores_gemma":[0.9546074,0.01994947,0.0104566,0.0003749148,0.0001903458,0.0001955658,0.0003840828,0.00003943787,0.0138022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002252552,"threshold_uncertainty_score":0.007535517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009023453301456253,"score_gpt":0.2515959901929952,"score_spread":0.242572536891539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}