{"id":"W2950392128","doi":"10.1371/journal.pgen.1006964","title":"rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; WorldQuant Foundation; Hospital for Sick Children; National Cancer Institute; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance; Memorial Sloan-Kettering Cancer Center; Carnegie Institution of Washington; Vallee Foundation; Bill and Melinda Gates Foundation; National Aeronautics and Space Administration; Howard Hughes Medical Institute","keywords":"Biology; Genetics; DNA methyltransferase; Retrotransposon; DNMT3B; DNA methylation; Synapsis; Methyltransferase; Transposable element; Mutant; Methylation; DNA; Meiosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004269209,0.0001636076,0.0002228029,0.000045927,0.000179272,0.00003954989,0.0003296678,0.0001900337,0.000008726965],"category_scores_gemma":[0.0001539995,0.0001317624,0.00009832765,0.00003680018,0.0001209866,0.000005773416,0.00005338174,0.00007570851,3.431507e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005956232,"about_ca_system_score_gemma":0.00003166509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001793438,"about_ca_topic_score_gemma":0.00008440331,"domain_scores_codex":[0.9988174,0.00009220712,0.0003404068,0.0003702707,0.0001574827,0.0002221988],"domain_scores_gemma":[0.9989324,0.00005056017,0.0001566946,0.0007148449,0.00009208114,0.00005346351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001396902,0.000124902,0.004799018,0.00007148484,0.00004715208,0.000002607587,0.0007239797,0.0000479901,0.9923083,0.00001611297,0.00002665034,0.001692132],"study_design_scores_gemma":[0.001024846,0.0004127802,0.001525644,0.00002664615,0.00009066983,0.000003146216,0.00008660525,0.001500216,0.9937209,0.0002407916,0.001201192,0.0001665134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929739,0.003628933,0.002112414,0.0004282651,0.00003069607,0.0005402837,0.0001154888,0.000003860339,0.0001661058],"genre_scores_gemma":[0.9923111,0.005069896,0.002216328,0.00008577712,0.00008315931,0.00006457091,0.00006877187,0.00002526267,0.00007517917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003273374,"threshold_uncertainty_score":0.5373116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04012933188640567,"score_gpt":0.2997907541936581,"score_spread":0.2596614223072524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}