{"id":"W2950392128","doi":"10.1371/journal.pgen.1006964","title":"rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; WorldQuant Foundation; Hospital for Sick Children; National Cancer Institute; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance; Memorial Sloan-Kettering Cancer Center; Carnegie Institution of Washington; Vallee Foundation; Bill and Melinda Gates Foundation; National Aeronautics and Space Administration; Howard Hughes Medical Institute","keywords":"Biology; Genetics; DNA methyltransferase; Retrotransposon; DNMT3B; DNA methylation; Synapsis; Methyltransferase; Transposable element; Mutant; Methylation; DNA; Meiosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451638,0.001008327,0.0004198078,0.001059612,0.0004132304,0.0002482017,0.0009259988,0.001068797,0.004714336],"category_scores_gemma":[0.0001299903,0.0003847178,0.0006255768,0.0003421419,0.0005757869,0.0001986439,0.0006392572,0.0009349639,0.001744935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004120849,"about_ca_system_score_gemma":0.0003594877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009854283,"about_ca_topic_score_gemma":0.00214005,"domain_scores_codex":[0.9997115,0.00003581492,0.00002697451,0.00007749032,0.0001008092,0.00004747951],"domain_scores_gemma":[0.9997749,0.00002607362,0.00008190907,0.00002879842,0.000009553532,0.00007885356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007257439,0.00003316967,0.0002323136,0.00002975974,0.00001355857,0.0003006017,0.00001714811,0.00004981285,0.9965068,0.0002855607,0.0001067377,0.002352021],"study_design_scores_gemma":[0.00008895958,0.0004596725,0.0133005,0.00002043993,0.00006066425,0.003855091,0.00005294303,0.001075051,0.9654282,0.0001943265,0.01543572,0.00002844822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713888,0.001661753,0.01262125,0.0002786696,0.00009815576,0.0003029021,0.004819626,0.002492268,0.00633654],"genre_scores_gemma":[0.942094,0.0009402373,0.01918412,0.000179735,0.0000225475,0.0003008479,0.004890787,0.0004342303,0.03195335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004714336,"threshold_uncertainty_score":0.01577103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04012933188640567,"score_gpt":0.2997907541936581,"score_spread":0.2596614223072524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}