{"id":"W2950458829","doi":"10.1101/126631","title":"Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Center for Advancing Translational Sciences; York University; Australian Government","keywords":"Glutamine; Glutaminase; Catabolism; Biochemistry; Biology; Cystine; Metabolism; Cell biology; Amino acid; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344782,0.0001782361,0.0003723635,0.0001303828,0.0001533346,0.000488102,0.0002055069,0.0002506727,0.001581935],"category_scores_gemma":[0.0002040889,0.0001201609,0.000165241,0.0001656438,0.0002321455,0.0001505863,0.0003768631,0.0004031011,0.0003407497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004716902,"about_ca_system_score_gemma":0.0002562223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869144,"about_ca_topic_score_gemma":0.002830738,"domain_scores_codex":[0.9998004,0.00003567924,0.00002382496,0.00003608323,0.00006234623,0.00004165236],"domain_scores_gemma":[0.9998123,0.00004315404,0.00004272163,0.00003853619,0.00003013428,0.00003317462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001399525,0.0000223988,0.0006850417,0.00003988025,0.000006269478,0.00006403943,0.00002212384,0.0001340881,0.9976967,0.00009812268,0.000133844,0.0009574831],"study_design_scores_gemma":[0.000009296368,0.00008564015,0.005693138,0.000006811254,0.000005300791,0.000117716,0.00004867047,0.0009215305,0.9900035,0.00004461903,0.00305954,0.000004049842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917088,0.001113621,0.002219198,0.0003070798,0.00005249974,0.00003093915,0.0008007397,0.000116809,0.003650253],"genre_scores_gemma":[0.9960976,0.0003097209,0.001088855,0.00009554157,0.000007883834,0.00001506995,0.0005664723,0.00003353683,0.001785485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869144,"threshold_uncertainty_score":0.005292118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007235015685296334,"score_gpt":0.2023865710455006,"score_spread":0.1951515553602043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}