{"id":"W2950501730","doi":"10.3389/fcimb.2019.00212","title":"The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans","year":2019,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Cryptococcus neoformans; Biology; Virulence; Protein kinase A; Signal transduction; Cell biology; Nutrient sensing; Saccharomyces cerevisiae; Phenotype; Metabolic pathway; Kinase; Yeast; Microbiology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003500777,0.0002918754,0.0009110792,0.0004909582,0.0002362902,0.00003313359,0.00004703585,0.0003454833,0.00001240253],"category_scores_gemma":[0.00009254686,0.0002062689,0.0001228847,0.0003930382,0.0002184234,0.0000673882,0.00007484136,0.0004577857,0.00002479757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802571,"about_ca_system_score_gemma":0.0001063264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002447129,"about_ca_topic_score_gemma":0.000290492,"domain_scores_codex":[0.9985291,0.0001949101,0.0005354893,0.0004000948,0.00003396685,0.0003064516],"domain_scores_gemma":[0.9994113,0.00009599587,0.0001602627,0.0002144222,0.00005548914,0.00006250782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002408155,0.0005030081,0.01132444,0.01470087,0.0006994796,0.00008215191,0.002031816,0.00004165814,0.01816759,0.001200988,0.008106945,0.9429002],"study_design_scores_gemma":[0.0006113691,0.0004257757,0.0004797763,0.002943018,0.0001508804,0.0001082071,0.0002063099,0.00007102263,0.0001482688,0.00007355138,0.9945166,0.0002652153],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01822283,0.9769565,0.0009141105,0.00008692766,0.001042924,0.002454403,0.00008160382,0.00002611475,0.0002146102],"genre_scores_gemma":[0.003249157,0.9949433,0.0003459906,0.00005716892,0.00006814791,0.0004183227,0.000195292,0.00002418139,0.0006984716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9864097,"threshold_uncertainty_score":0.8411403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165636848761846,"score_gpt":0.2695391354398648,"score_spread":0.2478827669522463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}