{"id":"W2950501730","doi":"10.3389/fcimb.2019.00212","title":"The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans","year":2019,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Cryptococcus neoformans; Biology; Virulence; Protein kinase A; Signal transduction; Cell biology; Nutrient sensing; Saccharomyces cerevisiae; Phenotype; Metabolic pathway; Kinase; Yeast; Microbiology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231333,0.0004895535,0.0006356331,0.001474006,0.0001852175,0.0006084968,0.0004020672,0.0006772975,0.001805468],"category_scores_gemma":[0.000261034,0.0001634694,0.0002683738,0.001230864,0.0003248562,0.0006003455,0.0004098495,0.0009220985,0.001043819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004961696,"about_ca_system_score_gemma":0.000750215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016711,"about_ca_topic_score_gemma":0.001544878,"domain_scores_codex":[0.9999317,0.000008650166,0.0000103537,0.00001504402,0.00002469616,0.00000956963],"domain_scores_gemma":[0.9999038,0.00003712144,0.00001840198,0.000002513769,0.0000246218,0.0000135081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000112345,0.00004960872,0.0001873201,0.0146416,0.00005804251,0.0001860835,0.00005214442,0.0003382377,0.00655912,0.002838215,0.01257049,0.9624069],"study_design_scores_gemma":[0.00002571658,0.0001694276,0.002591352,0.003727423,0.0001233801,0.00172117,0.00007970261,0.000165668,0.00244679,0.002236452,0.9866865,0.00002633567],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002573052,0.9986258,0.00007488845,0.0001527717,0.00008802408,0.000002719344,0.00001548073,0.000005200019,0.0007778301],"genre_scores_gemma":[0.001258733,0.9980193,0.0001036948,0.00009344512,0.00007074282,0.000003096663,0.00002384406,9.242614e-7,0.0004261706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001805468,"threshold_uncertainty_score":0.006039858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165636848761846,"score_gpt":0.2695391354398648,"score_spread":0.2478827669522463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}