{"id":"W2950522939","doi":"10.1002/chin.200603185","title":"High‐Yielding Synthesis of 3a‐Hydroxypyrrolo[2,3‐b]indoline Dipeptide Methyl Esters: Synthons for Expedient Introduction of the Hydroxypyrroloindoline Moiety into Larger Peptide‐Based Natural Products and for the Creation of Tryptathionine Bridges.","year":2005,"lang":"en","type":"article","venue":"ChemInform","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Synthon; Chemistry; Moiety; Dipeptide; Stereochemistry; Columbia university; Polymer science; Peptide; Sociology; Media studies","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974123,0.0003603756,0.0001535341,0.000164085,0.00009831704,0.0001508406,0.0003367967,0.000222108,0.001272186],"category_scores_gemma":[0.0001437259,0.0001614186,0.0001514171,0.0001419915,0.00009383812,0.0002923395,0.0002293875,0.0004382342,0.001257652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558031,"about_ca_system_score_gemma":0.0002531098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153574,"about_ca_topic_score_gemma":0.0005505313,"domain_scores_codex":[0.9999112,0.0000137762,0.000009752007,0.00001999807,0.00002356717,0.00002167166],"domain_scores_gemma":[0.9999279,0.000008916722,0.00002155943,0.0000133459,0.00001382621,0.00001445583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005389148,0.00001531553,0.0000525738,0.00008153995,0.000006075531,0.00009987188,0.00003645256,0.000167713,0.9936118,0.0003276025,0.00008994614,0.005457283],"study_design_scores_gemma":[0.00001277197,0.0001824912,0.0003751318,0.000005606064,0.000008163506,0.0002150554,0.0000131782,0.0005671043,0.9921364,0.00007333715,0.006401414,0.000009388856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8674498,0.004252302,0.1117344,0.0001881159,0.0001029216,0.0003898599,0.001961738,0.0007733573,0.01314752],"genre_scores_gemma":[0.933144,0.002603007,0.05625731,0.00005910823,0.00001770325,0.000171841,0.001593119,0.000136511,0.006017445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272186,"threshold_uncertainty_score":0.004255831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301782366640285,"score_gpt":0.2694527576677685,"score_spread":0.2564349340013656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}