{"id":"W2950532467","doi":"10.1021/ol050658n","title":"Morita−Baylis−Hillman Reaction and Cyclization of 1-(<i>p</i>-Toluenesulfonyl)-1,3-butadiene with Aldimines","year":2005,"lang":"en","type":"article","venue":"Organic Letters","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Aldimine; Chemistry; Adduct; Base (topology); Photoisomerization; 1,3-Butadiene; Catalysis; Baylis–Hillman reaction; Medicinal chemistry; Organic chemistry; Stereochemistry; Isomerization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006737753,0.0001116848,0.0001036719,0.00003651565,0.00003931625,0.000008234963,0.00006721311,0.00005850748,0.00001293868],"category_scores_gemma":[0.00003080569,0.00009153882,0.00001956791,0.00009965207,0.00005435041,0.00001102417,0.0000449139,0.00005123853,0.000001966521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000100733,"about_ca_system_score_gemma":0.00001334845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002554192,"about_ca_topic_score_gemma":0.00008653556,"domain_scores_codex":[0.9993827,0.00001728926,0.0001268681,0.0002542482,0.00008792971,0.0001309101],"domain_scores_gemma":[0.99962,0.000004460795,0.00008034408,0.0002022092,0.00005335618,0.00003963972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005609736,0.00001884163,0.001987453,0.00001829376,0.00002455062,9.384651e-7,0.00003339482,0.00001650476,0.9930058,0.00002649288,0.001130273,0.00368134],"study_design_scores_gemma":[0.0005952279,0.0001688944,0.01971672,0.00001181464,0.00002579913,0.00005737658,0.00002476923,0.00002671164,0.9642946,0.000006581887,0.01489188,0.0001795905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943391,0.0002903689,0.0001365013,0.004935191,0.00006182961,0.00009541988,0.0000033257,0.00001165315,0.0001265911],"genre_scores_gemma":[0.9974534,0.0002109205,0.0006752997,0.001046015,0.0003414759,0.000002301851,0.00007499509,0.00001947657,0.0001761384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02871119,"threshold_uncertainty_score":0.3732845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003285264638333831,"score_gpt":0.1901278491286003,"score_spread":0.1868425844902664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}