{"id":"W2950536465","doi":"10.1016/s0140-6736(19)31388-1","title":"Long-term safety and efficacy of veverimer in patients with metabolic acidosis in chronic kidney disease: a multicentre, randomised, blinded, placebo-controlled, 40-week extension","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Renal function and acid-base balance","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Commercial Aircraft of China","keywords":"Medicine; Kidney disease; Placebo; Internal medicine; Renal function; Metabolic acidosis; Adverse effect; Clinical endpoint; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003570626,0.00150821,0.00429484,0.0003616128,0.0004868314,0.001383986,0.001071157,0.003492007,0.00495344],"category_scores_gemma":[0.004660566,0.001058687,0.003218769,0.000466766,0.001530306,0.001808954,0.0005735724,0.003747017,0.0007419508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009916244,"about_ca_system_score_gemma":0.0009955064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137013,"about_ca_topic_score_gemma":0.001893471,"domain_scores_codex":[0.9983631,0.0008440675,0.000152123,0.0002434204,0.0001305635,0.0002667435],"domain_scores_gemma":[0.9975659,0.0009767828,0.0006147831,0.0002305956,0.0001792342,0.000432785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9888864,0.001266084,0.0003729393,0.000563207,0.0008995058,0.00001954017,0.00004147726,0.00009780852,0.001259322,0.00003471601,0.0002249022,0.006334175],"study_design_scores_gemma":[0.9509305,0.04394783,0.003182145,0.00006868879,0.0008830415,0.00002691827,0.00003076796,0.0001685634,0.0003377656,0.00008390514,0.0003150687,0.00002474601],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829988,0.011844,0.0006903695,0.000799527,0.0006168794,0.001135617,0.0006860369,0.00009147677,0.001137308],"genre_scores_gemma":[0.9908181,0.003575004,0.001069079,0.0008587732,0.0005074248,0.001022521,0.0004404162,0.00002509436,0.00168366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00495344,"threshold_uncertainty_score":0.01888353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173363392693732,"score_gpt":0.2541188079410334,"score_spread":0.2423851740140961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}