{"id":"W2950536465","doi":"10.1016/s0140-6736(19)31388-1","title":"Long-term safety and efficacy of veverimer in patients with metabolic acidosis in chronic kidney disease: a multicentre, randomised, blinded, placebo-controlled, 40-week extension","year":2019,"lang":"en","type":"article","venue":"The Lancet","topic":"Renal function and acid-base balance","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Commercial Aircraft of China","keywords":"Medicine; Kidney disease; Placebo; Internal medicine; Renal function; Metabolic acidosis; Adverse effect; Clinical endpoint; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003426497,0.0001841308,0.000952072,0.0001081893,0.00002601463,0.00001119111,0.0001023971,0.00004794242,0.0001576556],"category_scores_gemma":[0.0002872426,0.0001028212,0.00007682842,0.0002251331,0.00006965568,0.00007936768,0.00003794035,0.0002131652,0.00003119087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006151481,"about_ca_system_score_gemma":0.0001394994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003506547,"about_ca_topic_score_gemma":0.0000202544,"domain_scores_codex":[0.9986562,0.0001463266,0.000354796,0.0002763203,0.0002835825,0.0002828422],"domain_scores_gemma":[0.9989304,0.0002188264,0.0001577496,0.0004790191,0.0000608613,0.0001531683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4325948,0.0003505739,0.5636597,0.0001410231,0.00008901364,0.000009235867,0.00008877584,0.0001650194,0.001210811,0.00001397476,0.00008960128,0.001587487],"study_design_scores_gemma":[0.3344871,0.0001364676,0.6634138,0.0004872964,0.0001229327,0.000001043275,0.000006514191,0.0006403501,0.0003193964,0.000001565801,0.000299774,0.00008382487],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944189,0.002250229,0.00001729117,0.0005974384,0.00009552479,0.002390895,0.00002396815,0.00001910779,0.000186694],"genre_scores_gemma":[0.9980729,0.0007256793,0.00003459326,0.0007091994,0.000112226,0.00003735267,0.00004867389,0.00001919097,0.0002401576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09975404,"threshold_uncertainty_score":0.4192927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173363392693732,"score_gpt":0.2541188079410334,"score_spread":0.2423851740140961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}