{"id":"W2950541136","doi":"10.1038/s41467-019-10461-0","title":"Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; BC Children's Hospital; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Mental Health; National Institutes of Health; University of Cape Town; South African Medical Research Council; Sigrid Juséliuksen Säätiö; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; Juho Vainion Säätiö; Fogarty International Center; Jane ja Aatos Erkon Säätiö; Suomen Lääketieteen Säätiö; Academy of Finland; Päivikki ja Sakari Sohlbergin Säätiö; Helse- og Omsorgsdepartementet; Novo Nordisk; Bundesministerium für Bildung und Forschung; School of Medicine, Emory University; Novo Nordisk Fonden; Lastentautien Tutkimussäätiö; Norges Forskningsråd; Emory University; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Tommy's; Wellcome Trust; Technische Universität München; Helsingin Yliopisto; European Commission; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Bill and Melinda Gates Foundation","keywords":"DNA methylation; Cord blood; Genetics; Epigenetics; Biology; DNA; Computational biology; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001014237,0.00008551795,0.0001347608,0.0001872872,0.00003057885,0.000009471365,0.0002497702,0.0002070174,0.00001961741],"category_scores_gemma":[0.00005260992,0.00008231031,0.00005096955,0.0002946914,0.00005741118,0.000003681151,0.0001039836,0.0001896091,0.000002243566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009634525,"about_ca_system_score_gemma":0.00003527059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004296075,"about_ca_topic_score_gemma":0.0007721236,"domain_scores_codex":[0.99935,0.0001036194,0.0002043825,0.0001771798,0.00008932806,0.0000755155],"domain_scores_gemma":[0.9990527,0.000061485,0.0001056263,0.0007218757,0.00002444776,0.00003385923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001938079,0.00007579693,0.2787324,0.000001779929,0.0001369605,7.302722e-8,0.00004906127,0.0003110482,0.7155389,0.0001714724,0.00000582264,0.004957287],"study_design_scores_gemma":[0.0002887609,0.0001836323,0.9099811,0.000006637805,0.0001685769,2.452315e-7,0.00005278434,0.0006745994,0.08554617,0.00008402303,0.002919261,0.00009419934],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901155,0.009089541,0.00005325578,0.0001214866,0.00002420173,0.0001427218,0.00004070411,0.000003160162,0.0004094468],"genre_scores_gemma":[0.9942751,0.002668531,0.002500161,0.00005594305,0.000008778968,0.000004609577,0.0004037445,0.00000698249,0.00007616008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6312487,"threshold_uncertainty_score":0.3356517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019461539821504,"score_gpt":0.2808939194319016,"score_spread":0.2706993040336865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}