{"id":"W2950541136","doi":"10.1038/s41467-019-10461-0","title":"Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; BC Children's Hospital; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Mental Health; National Institutes of Health; University of Cape Town; South African Medical Research Council; Sigrid Juséliuksen Säätiö; Medical Research Council; Signe ja Ane Gyllenbergin Säätiö; Juho Vainion Säätiö; Fogarty International Center; Jane ja Aatos Erkon Säätiö; Suomen Lääketieteen Säätiö; Academy of Finland; Päivikki ja Sakari Sohlbergin Säätiö; Helse- og Omsorgsdepartementet; Novo Nordisk; Bundesministerium für Bildung und Forschung; School of Medicine, Emory University; Novo Nordisk Fonden; Lastentautien Tutkimussäätiö; Norges Forskningsråd; Emory University; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Tommy's; Wellcome Trust; Technische Universität München; Helsingin Yliopisto; European Commission; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Bill and Melinda Gates Foundation","keywords":"DNA methylation; Cord blood; Genetics; Epigenetics; Biology; DNA; Computational biology; Bioinformatics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008573887,0.0002329214,0.000399407,0.0005777174,0.0002687256,0.0004145445,0.000329778,0.0002353213,0.001236902],"category_scores_gemma":[0.002237208,0.0001780853,0.0005128864,0.0006362837,0.000214883,0.0001333359,0.0005299766,0.0003834623,0.0001405884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002933301,"about_ca_system_score_gemma":0.000343174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01052197,"about_ca_topic_score_gemma":0.01544529,"domain_scores_codex":[0.9994714,0.0001351773,0.00003475574,0.0001911896,0.0001092091,0.00005825612],"domain_scores_gemma":[0.9990883,0.0003181946,0.0002415476,0.0001635877,0.0000811248,0.0001072497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009002294,0.00002679813,0.9504751,0.00004440348,0.0006733609,0.0003235496,0.000326346,0.0006618781,0.02917,0.000227884,0.0001223586,0.01704813],"study_design_scores_gemma":[0.00000554543,0.00006118947,0.9958647,0.000007403894,0.0001211012,0.0002427365,0.00006779868,0.0005632527,0.002548261,0.0001431864,0.000369671,0.000005124416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979239,0.0002836767,0.0009699832,0.00001805247,0.000005057604,0.000003623283,0.0004917337,0.00001025691,0.0002937058],"genre_scores_gemma":[0.9975564,0.0002228184,0.001073546,0.00001995249,0.00000465596,0.000008033286,0.0005652565,0.00001574187,0.0005335279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052197,"threshold_uncertainty_score":0.02092147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019461539821504,"score_gpt":0.2808939194319016,"score_spread":0.2706993040336865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}