{"id":"W2950620394","doi":"10.1097/01.hs9.0000561796.30124.a4","title":"S879 RESULTS OF ASTRAL‐1 STUDY, A PHASE 3 RANDOMIZED TRIAL OF GUADECITABINE (G) VS TREATMENT CHOICE (TC) IN TREATMENT NAÏVE ACUTE MYELOID LEUKEMIA (TN‐AML) NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY (IC)","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta Hospital; Alberta Hospital Edmonton","funders":"","keywords":"Medicine; Decitabine; Internal medicine; Clinical endpoint; Cytarabine; Randomized controlled trial; Regimen; Induction chemotherapy; Oncology; Gastroenterology; Chemotherapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001109428,0.0007112998,0.003653042,0.0003328299,0.00005094342,0.00002181059,0.0003108768,0.0003228406,0.0003213056],"category_scores_gemma":[0.001010835,0.0004994931,0.0009154184,0.0006398528,0.000226636,0.0001453927,0.00007619598,0.0003029477,0.00004966025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002692611,"about_ca_system_score_gemma":0.001676247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003179727,"about_ca_topic_score_gemma":0.0003523414,"domain_scores_codex":[0.9951363,0.00033116,0.00196898,0.0009965251,0.0007439044,0.0008231106],"domain_scores_gemma":[0.9947783,0.002110452,0.0007423189,0.001285231,0.0008366204,0.0002471268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9210572,0.005383587,0.0002517357,0.0001792754,0.00286109,0.00008454725,0.004840673,0.00003663373,0.04688104,0.00002123594,0.001438993,0.01696397],"study_design_scores_gemma":[0.7677485,0.03266149,0.0001570868,0.0002424062,0.0007626661,0.00001908683,0.002705367,0.0006644326,0.1917008,0.00002121539,0.003037528,0.0002793244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754093,0.0004270462,0.00005918652,0.001389707,0.0002562076,0.02090269,0.0003362811,0.00005854683,0.001160991],"genre_scores_gemma":[0.9821744,0.001031225,0.001846864,0.0001761165,0.0002954349,0.001832034,0.0003292458,0.0001286179,0.01218606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1533087,"threshold_uncertainty_score":0.9997457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03473661491423022,"score_gpt":0.3619602162914029,"score_spread":0.3272236013771727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}