{"id":"W2950639183","doi":"10.1155/2019/5320747","title":"Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1","year":2019,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protein kinase R; EIF-2 kinase; Cell growth; Gene knockdown; Cell biology; Biology; Translation (biology); Protein kinase A; Kinase; Apoptosis; Signal transduction; eIF2; Molecular biology; Messenger RNA; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096719,0.0003629006,0.0003573287,0.0002507405,0.000256025,0.0003668472,0.0002021499,0.0003453442,0.0004769826],"category_scores_gemma":[0.0001599101,0.0001422394,0.0002743696,0.0001123377,0.0003560494,0.0002707687,0.0002384178,0.0005039925,0.0001934381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002838679,"about_ca_system_score_gemma":0.0002252777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002683352,"about_ca_topic_score_gemma":0.0002974799,"domain_scores_codex":[0.9998145,0.00004265967,0.00002692622,0.0000423099,0.00004166105,0.00003199196],"domain_scores_gemma":[0.9998858,0.00002335148,0.00003841712,0.00001199473,0.00001358778,0.00002685415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002545133,0.00005919133,0.0003628955,0.000154553,0.00001080106,0.0002559751,0.0000223131,0.000138816,0.9958109,0.0003595493,0.00006622442,0.002504306],"study_design_scores_gemma":[0.00005380572,0.0005043133,0.01498994,0.00002341787,0.00003800044,0.001354318,0.00004839581,0.001776063,0.9763386,0.0002438458,0.004614798,0.00001463492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687933,0.02374927,0.003446482,0.0003875775,0.0001174381,0.00004137185,0.0002151568,0.0001613889,0.003088111],"genre_scores_gemma":[0.9924726,0.004483972,0.001555993,0.00007814493,0.00002352707,0.00002869453,0.0001428198,0.00001151898,0.001202634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004769826,"threshold_uncertainty_score":0.002059639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724755999129817,"score_gpt":0.3148989591997615,"score_spread":0.2976513992084633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}