{"id":"W2950639183","doi":"10.1155/2019/5320747","title":"Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1","year":2019,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protein kinase R; EIF-2 kinase; Cell growth; Gene knockdown; Cell biology; Biology; Translation (biology); Protein kinase A; Kinase; Apoptosis; Signal transduction; eIF2; Molecular biology; Messenger RNA; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000377836,0.00003592649,0.00004309612,0.00009041903,0.00001324621,0.000008856569,0.0000871551,0.00004493536,0.00002586169],"category_scores_gemma":[0.00006337364,0.00002769182,0.00001859847,0.00008508582,0.00007808659,0.000004212,0.00002317876,0.00004027275,0.000001748119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005197539,"about_ca_system_score_gemma":0.00004856371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000308094,"about_ca_topic_score_gemma":0.000008417214,"domain_scores_codex":[0.9993094,0.00009197596,0.0001301119,0.0001093967,0.0002825996,0.0000765568],"domain_scores_gemma":[0.9997325,0.00002287398,0.00003368264,0.00008079073,0.000108542,0.00002160899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001195037,0.00007542992,0.008586005,0.00001511609,0.000009274299,9.563069e-8,0.0001090652,0.000002434178,0.9883778,0.0001055807,0.001075883,0.001523807],"study_design_scores_gemma":[0.0008096372,0.000286681,0.04266598,0.0000266973,0.000002484359,0.000002919543,0.000465908,0.0004875975,0.9453939,0.0005931002,0.00921289,0.00005222025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972456,0.0005266616,0.0000579441,0.0005046364,0.00003753256,0.0002218498,0.00007211756,8.518214e-7,0.001332821],"genre_scores_gemma":[0.9993197,0.00006502083,0.0001005198,0.00002239954,0.00004818391,0.00001740468,0.0003037211,0.000003221853,0.0001198656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04298392,"threshold_uncertainty_score":0.112924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724755999129817,"score_gpt":0.3148989591997615,"score_spread":0.2976513992084633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}