{"id":"W2950641146","doi":"10.1002/chin.200137217","title":"ChemInform Abstract: Backbone Modifications of Aromatic Peptide Nucleic Acid (APNA) Monomers and Their Hybridization Properties with DNA and RNA.","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Nucleic acid; DNA; RNA; Monomer; Peptide nucleic acid; Combinatorial chemistry; Nucleic acid thermodynamics; Peptide; Computational biology; Biochemistry; Organic chemistry; Base sequence; Gene; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685115,0.000444535,0.0001808237,0.000282358,0.0002205611,0.0002313758,0.0003185193,0.0003281498,0.01282829],"category_scores_gemma":[0.0003671091,0.0002070625,0.0001294842,0.0002855038,0.0001332929,0.0003639587,0.0001746529,0.0004913737,0.003092756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090989,"about_ca_system_score_gemma":0.0001899949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003453329,"about_ca_topic_score_gemma":0.0004847805,"domain_scores_codex":[0.9998705,0.00002199773,0.000005733398,0.00002064739,0.00006277643,0.00001820515],"domain_scores_gemma":[0.9998915,0.00003123862,0.00002528357,0.000009035311,0.00001940175,0.00002347473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004669972,0.00005335556,0.0001923844,0.0002629786,0.0000160134,0.00008261098,0.00002413245,0.0003245588,0.9734715,0.0004642972,0.003978338,0.02066289],"study_design_scores_gemma":[0.00001813198,0.0002251436,0.001055068,0.000008434694,0.0000153075,0.00009845235,0.000007888106,0.0003114498,0.9886419,0.0001017634,0.009509407,0.000007072781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8493665,0.03074593,0.03498428,0.001065298,0.001285647,0.0002048036,0.006751901,0.001645186,0.07395053],"genre_scores_gemma":[0.8819733,0.01185977,0.01561174,0.0006149962,0.0002004497,0.00013312,0.009499623,0.0002666935,0.07984027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01282829,"threshold_uncertainty_score":0.04291493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042574189437309,"score_gpt":0.1939340756436885,"score_spread":0.1835083337493154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}