{"id":"W2950655293","doi":"10.1101/gr.232330.117","title":"Transposon insertional mutagenesis in <i>Saccharomyces uvarum</i> reveals <i>trans</i> -acting effects influencing species-dependent essential genes","year":2019,"lang":"en","type":"article","venue":"Genome Research","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Los Alamos National Laboratory; Natural Sciences and Engineering Research Council of Canada; National Nuclear Security Administration; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; American Society for Microbiology; U.S. Department of Energy; Howard Hughes Medical Institute; National Science Foundation","keywords":"Biology; Genetics; Gene; Complementation; Insertional mutagenesis; Saccharomyces cerevisiae; Genome; Transposable element; Forward genetics; Mutagenesis; Phenotype; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535777,0.0005345948,0.0002507202,0.0003415047,0.0001551691,0.0003309232,0.0003358118,0.0002828562,0.0009030316],"category_scores_gemma":[0.0002477581,0.0001858586,0.000352573,0.000270071,0.0002789789,0.0001478041,0.0002950457,0.0006100932,0.0003451974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004756634,"about_ca_system_score_gemma":0.0003389655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629995,"about_ca_topic_score_gemma":0.002274765,"domain_scores_codex":[0.9997424,0.00004798939,0.00003091433,0.00006894647,0.00007449056,0.00003531099],"domain_scores_gemma":[0.999726,0.00008302527,0.00009637458,0.00003699815,0.00001901924,0.00003851842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001924418,0.000008407922,0.0001470668,0.000008750556,0.000002645829,0.0000179892,0.000006358155,0.00003998088,0.9992473,0.00003835047,0.000004981472,0.0004588596],"study_design_scores_gemma":[0.000004799603,0.00008792915,0.004347333,0.000005355273,0.00001975869,0.0001718772,0.00003245742,0.0007190873,0.9936057,0.00004541775,0.0009532353,0.000006847657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985122,0.0003970972,0.01190932,0.00007877427,0.00002413613,0.00005972741,0.0009839589,0.0003196336,0.001105356],"genre_scores_gemma":[0.9889073,0.0004109,0.007766049,0.00007058631,0.000006293743,0.00002893217,0.001115569,0.0001557251,0.001538716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629995,"threshold_uncertainty_score":0.003451169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204668265713714,"score_gpt":0.3008770056513425,"score_spread":0.2788303229942053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}