{"id":"W2950660527","doi":"10.1016/j.celrep.2017.07.078","title":"Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Immune system; Biology; Innate immune system; Progenitor cell; Cell biology; Progenitor; Immunology; Carcinogenesis; Innate lymphoid cell; Immunity; Stem cell; Homeostasis; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006993508,0.000311985,0.0004908012,0.0001160897,0.0006853837,0.00008321966,0.0003807805,0.0002893249,0.0002222845],"category_scores_gemma":[0.0003140939,0.0002954217,0.000142527,0.00006759279,0.000779273,0.0002580392,0.0003074328,0.0004489769,0.0003963703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201763,"about_ca_system_score_gemma":0.0003623503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009688,"about_ca_topic_score_gemma":0.00005874346,"domain_scores_codex":[0.9980381,0.0002303837,0.0005240105,0.0005846802,0.0000661172,0.0005567037],"domain_scores_gemma":[0.9977987,0.00009899677,0.0007402805,0.001204453,0.0001200462,0.00003749026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001868496,0.0003330688,0.0018806,0.00003341561,0.00003791084,0.002149286,0.0001690001,0.00000107945,0.9936703,0.0004638685,0.00006245128,0.001012153],"study_design_scores_gemma":[0.0005889229,0.0001549858,0.006167298,0.00008839234,0.00003327516,0.001708215,0.00004640804,0.000006022074,0.988556,0.0008256771,0.001510112,0.0003146486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845442,0.0006646359,0.00006084306,0.00007965192,0.002745363,0.0007372538,0.000006928657,0.00008827507,0.01107283],"genre_scores_gemma":[0.9959345,0.00001203023,0.0002038587,0.00002328094,0.0000376955,0.00009420143,0.00001586342,0.00003093978,0.003647669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01139024,"threshold_uncertainty_score":0.9999498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509467020994343,"score_gpt":0.2422008418737363,"score_spread":0.2271061716637929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}