{"id":"W2950732340","doi":"10.1101/156331","title":"Polygenic hazard scores in preclinical Alzheimer’s disease","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Medical Research Council; University of California, Irvine; GlaxoSmithKline; University of California, San Francisco; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; University of Washington; University of California, Los Angeles; National Institutes of Health; Eli Lilly and Company; Hersenstichting; AstraZeneca; Genentech; Norges Forskningsråd; University of California, Davis; University of Southern California; Eisai; Stichting MS Research; Newcastle University; Vanderbilt University; American Society of Neuroradiology; Northern California Institute for Research and Education; University of Pittsburgh; University of California, San Diego; Johns Hopkins University; Rush University; F. Hoffmann-La Roche; Medpace; York University; Nasjonalforeningen for Folkehelsen; Emory University; University of Pennsylvania; U.S. Department of Veterans Affairs; Elan; Office of Research and Development; Universitat de Barcelona; Radiological Society of North America; Massachusetts General Hospital; Northwestern University; University of Miami; Alzheimer's Research Trust; North Bristol NHS Trust; Bristol-Myers Squibb; Synarc; Dana Foundation; Wellcome Trust; Novartis; Alzheimer's Association","keywords":"Asymptomatic; Dementia; Hazard ratio; Disease; Medicine; Apolipoprotein E; Gerontology; Incidence (geometry); Alzheimer's disease; Cognitive decline; Internal medicine; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002105204,0.0003768296,0.0002586276,0.001180146,0.0002273989,0.0007939296,0.0002362254,0.0004161544,0.002734967],"category_scores_gemma":[0.007883827,0.0001442761,0.0004639711,0.000988489,0.0003633356,0.0004717734,0.0005883696,0.0005484855,0.0002815247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002530461,"about_ca_system_score_gemma":0.0002770633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003432046,"about_ca_topic_score_gemma":0.001889772,"domain_scores_codex":[0.9994246,0.0003199598,0.0000342957,0.0001031281,0.00006480892,0.00005323303],"domain_scores_gemma":[0.9958741,0.001958305,0.0012113,0.0004022633,0.0001977655,0.0003562649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004677001,0.00008392602,0.9710063,0.00003570204,0.000428965,0.0001817436,0.00009946037,0.002072609,0.0006014307,0.002435403,0.001227055,0.02135967],"study_design_scores_gemma":[0.00002604646,0.0001765899,0.9757877,0.00001868247,0.0001482259,0.0004133977,0.00006618572,0.01318584,0.0002795738,0.009171853,0.0007052838,0.00002055099],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892138,0.0008482218,0.005997458,0.0005555623,0.00003677038,0.00001861459,0.00160467,0.0000590062,0.001665901],"genre_scores_gemma":[0.9984487,0.0001081283,0.000646932,0.00003176925,0.00002849863,0.000005587257,0.0004477985,0.000003700538,0.0002788577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003432046,"threshold_uncertainty_score":0.01113355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05437158383843127,"score_gpt":0.3409088803372257,"score_spread":0.2865372964987944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}