{"id":"W2950755947","doi":"10.1021/ol0617291","title":"Total Synthesis of Topopyrones B and D","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Total synthesis; Combinatorial chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002651754,0.001095722,0.0006271985,0.0009254757,0.000724899,0.0004430501,0.0008186366,0.0004887164,0.01216866],"category_scores_gemma":[0.0002656575,0.0002948981,0.0003728482,0.0009748455,0.0002956159,0.0004569214,0.0006466361,0.0008618696,0.003470166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000670416,"about_ca_system_score_gemma":0.001905258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002258593,"about_ca_topic_score_gemma":0.002706169,"domain_scores_codex":[0.9997161,0.00002458058,0.00002366088,0.00006920657,0.00005880867,0.0001076409],"domain_scores_gemma":[0.9998854,0.000009695125,0.0000113678,0.00001500773,0.00002107977,0.00005739049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001526535,0.0005457967,0.0005287493,0.004681726,0.0002299477,0.002756899,0.0002409087,0.006290439,0.8031474,0.01473013,0.03082697,0.1344945],"study_design_scores_gemma":[0.0006663069,0.003398071,0.001166557,0.0001683305,0.000154722,0.001110464,0.00008327625,0.001478718,0.8088335,0.001949407,0.1808245,0.0001661484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4505728,0.03704194,0.2003896,0.00260255,0.005513109,0.01020599,0.07003058,0.006219867,0.2174235],"genre_scores_gemma":[0.8626741,0.02401968,0.07391976,0.0008042362,0.0001592143,0.001687586,0.007087597,0.0001830434,0.0294649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01216866,"threshold_uncertainty_score":0.04070818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003425468565147369,"score_gpt":0.1868313811626494,"score_spread":0.1834059125975021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}