{"id":"W2950755947","doi":"10.1021/ol0617291","title":"Total Synthesis of Topopyrones B and D","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Total synthesis; Combinatorial chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003162019,0.00005443614,0.00006293494,0.00001226292,0.0000178454,0.000005443606,0.00003932544,0.00003346885,0.0000267284],"category_scores_gemma":[0.000004093281,0.00005194641,0.0000236871,0.00002303033,0.00003068912,9.284448e-7,0.00002766114,0.00001639547,0.000001441103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004397454,"about_ca_system_score_gemma":0.000009562388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004114681,"about_ca_topic_score_gemma":0.00001639302,"domain_scores_codex":[0.9996893,0.000007785679,0.00007001116,0.0001105138,0.00004092365,0.00008139791],"domain_scores_gemma":[0.999837,0.000004373323,0.00002757352,0.000107495,0.000008781934,0.00001478237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009166995,0.000009874495,0.0002078092,0.000006019379,0.00001378895,6.419409e-7,0.000006463852,0.000001619508,0.9976988,0.0002044431,0.0005152608,0.00132604],"study_design_scores_gemma":[0.0001229003,0.00003175064,0.001309172,0.000003329941,0.00001373439,0.00001098947,0.00001130686,0.000002819921,0.996042,0.00005233119,0.002333975,0.00006573109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978476,0.0002606547,0.0009587189,0.0006846152,0.00006351182,0.00003431373,0.000005847403,0.000003825716,0.000140968],"genre_scores_gemma":[0.999075,0.0000382426,0.0002611704,0.0004061079,0.0001148279,0.00000305769,0.000005263958,0.0000105608,0.00008577055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818714,"threshold_uncertainty_score":0.2118313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003425468565147369,"score_gpt":0.1868313811626494,"score_spread":0.1834059125975021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}