{"id":"W2950772595","doi":"10.1038/s41467-018-03260-6","title":"A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Heart and Stroke Foundation of Canada","keywords":"Biobank; Genome-wide association study; Transcriptome; Stenosis; Disease; Medicine; Aortic valve stenosis; Aortic valve; Internal medicine; Cardiology; Gene; Bioinformatics; Biology; Genetics; Gene expression; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005044182,0.0001882853,0.0002998246,0.0005292466,0.0004411053,0.0006803098,0.0002017497,0.0003580634,0.002234052],"category_scores_gemma":[0.001185512,0.0001852717,0.0003732779,0.0006992805,0.0003089887,0.0001051775,0.0003812269,0.0004572285,0.0002003635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545074,"about_ca_system_score_gemma":0.0001579502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001449155,"about_ca_topic_score_gemma":0.002033649,"domain_scores_codex":[0.9996853,0.00008102199,0.0000240789,0.0001053202,0.00006694206,0.00003739988],"domain_scores_gemma":[0.9993043,0.0002798913,0.0001659065,0.00009410836,0.00005853009,0.00009723273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002399144,0.0001733767,0.7849493,0.0001915094,0.00111051,0.002950108,0.0004310831,0.0004212927,0.1907677,0.0003510033,0.001380371,0.01487456],"study_design_scores_gemma":[0.00004827613,0.00007767419,0.9939914,0.00001330324,0.0002459472,0.001337503,0.0001185423,0.000542332,0.002692275,0.0001731902,0.0007519698,0.000007600549],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977987,0.0003583278,0.000556218,0.0001174544,0.00001406882,0.000004695784,0.0006630864,0.00001545396,0.000471955],"genre_scores_gemma":[0.9984658,0.0001380925,0.0005810999,0.00004998704,0.00001029298,0.000004457281,0.0004742759,0.000005186523,0.0002709337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234052,"threshold_uncertainty_score":0.007473588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02953170745620818,"score_gpt":0.3946319192843195,"score_spread":0.3651002118281113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}