{"id":"W2950828127","doi":"10.1101/gad.324319.119","title":"KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Biology; Transcription factor; KLF4; Transcriptional regulation; Cell biology; Transcription (linguistics); Protein–protein interaction; Protein stability; DNA-binding protein; Genetics; Computational biology; SOX2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363806,0.0002767339,0.0002135469,0.0000661032,0.0001074262,0.00004679228,0.0001892381,0.0001739278,0.0004100013],"category_scores_gemma":[0.00001539258,0.0002278731,0.00007987471,0.000112956,0.00006290949,0.00002454488,0.00002432648,0.0001525085,0.00003799827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692066,"about_ca_system_score_gemma":0.000350837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007749245,"about_ca_topic_score_gemma":0.000124286,"domain_scores_codex":[0.9980987,0.0001083791,0.0003433709,0.0005820816,0.000463943,0.0004035045],"domain_scores_gemma":[0.9992586,0.000008535205,0.00008640625,0.0003039998,0.0002120452,0.0001303718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006273112,0.0001318772,0.03366999,0.00004996166,0.0001250498,7.885362e-7,0.000227744,0.0000545927,0.9627455,0.00001278329,0.0001830557,0.002171318],"study_design_scores_gemma":[0.001250381,0.0003145938,0.07913587,0.00003052328,0.00001071075,0.000004959656,0.000178319,0.00003245106,0.8497577,0.00001096129,0.06896765,0.0003058814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943069,0.0004542837,0.003625774,0.0001194246,0.0001693217,0.001081447,0.00006476627,0.00003369397,0.0001443936],"genre_scores_gemma":[0.9969276,0.00003440008,0.0007420145,0.00004703629,0.00003839062,0.0001172058,0.0008412419,0.0000349347,0.001217177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1129878,"threshold_uncertainty_score":0.9292395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124485671782416,"score_gpt":0.2274691415597764,"score_spread":0.2162242848419523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}