{"id":"W2950828186","doi":"10.1002/ana.25530","title":"Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition","year":2019,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Innovate UK; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Rosetrees Trust; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Parkinson's UK; Northern California Institute for Research and Education; Medical Research Council; Meso Scale Diagnostics; Medical Research Council Canada; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; UK Dementia Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Alzheimer's disease; Medicine; Amyloid (mycology); Genetics; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002144399,0.0002177432,0.0003550559,0.00005000632,0.0001082337,0.000008199399,0.000241341,0.0002787928,0.00004309728],"category_scores_gemma":[0.0004116968,0.0002169877,0.0003291994,0.00004921377,0.00009013598,0.000003056696,0.00008492777,0.00009844898,0.00002196124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002091586,"about_ca_system_score_gemma":0.00005786697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001685629,"about_ca_topic_score_gemma":0.00004871486,"domain_scores_codex":[0.9981025,0.0002537442,0.0004873453,0.0006450322,0.00007940814,0.0004320128],"domain_scores_gemma":[0.998316,0.0002843134,0.0004999797,0.0005445461,0.0002164084,0.0001386846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001517645,0.0001877372,0.9463356,0.00002990306,0.000531562,0.00000176098,0.00003919792,0.003191712,0.02025784,0.00002207251,0.01720537,0.01067962],"study_design_scores_gemma":[0.00104182,0.00186119,0.9543697,0.000003430393,0.0003489456,0.000002320774,0.000004887141,0.005826679,0.005851076,0.004440334,0.02599652,0.000253091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975921,0.00288408,0.01669507,0.00143772,0.0003140664,0.0007960029,0.001907417,0.00001026056,0.00003441553],"genre_scores_gemma":[0.9893487,0.001267505,0.004499714,0.003781028,0.0003643177,0.0001786507,0.0004511687,0.00004302947,0.00006587808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01440676,"threshold_uncertainty_score":0.8848502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788340351557129,"score_gpt":0.2960425122065014,"score_spread":0.2681591086909301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}