{"id":"W2950828186","doi":"10.1002/ana.25530","title":"Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition","year":2019,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Innovate UK; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Rosetrees Trust; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Parkinson's UK; Northern California Institute for Research and Education; Medical Research Council; Meso Scale Diagnostics; Medical Research Council Canada; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; UK Dementia Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Alzheimer's disease; Medicine; Amyloid (mycology); Genetics; Biology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347253,0.0007825505,0.0004262233,0.0009769654,0.0003164824,0.0008917842,0.0002967154,0.0006105635,0.002507668],"category_scores_gemma":[0.005307158,0.0002100516,0.001127077,0.00112843,0.0005659118,0.0004265957,0.0006773023,0.0007291579,0.0003709642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965684,"about_ca_system_score_gemma":0.000468768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002351069,"about_ca_topic_score_gemma":0.003042291,"domain_scores_codex":[0.9985517,0.0004778629,0.0001296804,0.0005186326,0.0002208195,0.0001013636],"domain_scores_gemma":[0.9970897,0.001137894,0.001142326,0.0003170984,0.0001448152,0.0001682698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003738571,0.00005170381,0.9830497,0.00006377047,0.0009210681,0.0003563938,0.00009042174,0.0009728502,0.002914425,0.0004779886,0.0002888384,0.01043892],"study_design_scores_gemma":[0.00002488814,0.0001325512,0.9892396,0.00004316032,0.0003651698,0.001253551,0.00007120347,0.004182169,0.0006965185,0.003178275,0.0007958543,0.00001709027],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927472,0.0008162073,0.003041002,0.00051804,0.00003142612,0.00001657163,0.001362158,0.00005909224,0.001408128],"genre_scores_gemma":[0.9979222,0.0001836027,0.0009823453,0.00005406177,0.00002227748,0.000006501853,0.0006488818,0.000008141599,0.0001720669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002507668,"threshold_uncertainty_score":0.008388937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02788340351557129,"score_gpt":0.2960425122065014,"score_spread":0.2681591086909301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}