{"id":"W2950849737","doi":"10.3389/fmicb.2019.01328","title":"Adaptive Evolution of Human-Isolated H5Nx Avian Influenza A Viruses","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Diabetes Canada","funders":"Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Biology; Influenza A virus subtype H5N1; Highly pathogenic; Host (biology); Adaptive evolution; Evolutionary biology; Convergent evolution; Viral evolution; Positive selection; Selection (genetic algorithm); Genome; Adaptation (eye); Virology; Genetics; Phylogenetics; Gene; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000316328,0.0002025827,0.0002362414,0.0004092404,0.0002209528,0.0002993337,0.0001484902,0.0002154577,0.0006981851],"category_scores_gemma":[0.000420861,0.00007085461,0.0002116382,0.0003437895,0.0002538704,0.0001603188,0.0001752566,0.0001797956,0.0001133069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002451487,"about_ca_system_score_gemma":0.0001408672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001257131,"about_ca_topic_score_gemma":0.001810789,"domain_scores_codex":[0.9998487,0.00003618702,0.000008296243,0.0000449245,0.00003397559,0.00002781037],"domain_scores_gemma":[0.9997396,0.00006363937,0.00008111384,0.00001697437,0.00004677951,0.0000517954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008180237,0.00007544958,0.484928,0.00008708178,0.000135327,0.000452379,0.0003553697,0.001488998,0.4965596,0.0002552316,0.00008579239,0.01475886],"study_design_scores_gemma":[0.00001184106,0.0004220555,0.9725162,0.00001051588,0.00005578121,0.0008945416,0.0003857964,0.003073238,0.02170671,0.0001442009,0.0007657518,0.0000133006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993781,0.0001419827,0.0001795906,0.00000490594,0.000001424077,0.000002285673,0.00004123901,0.00000181357,0.0002486414],"genre_scores_gemma":[0.999467,0.0000610607,0.0002573899,0.000008603983,0.000001961414,0.00000178163,0.0001004767,0.000002056725,0.00009978353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257131,"threshold_uncertainty_score":0.00249958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04072190234478524,"score_gpt":0.3364121422612869,"score_spread":0.2956902399165016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}