{"id":"W2950856878","doi":"10.1634/theoncologist.2019-0019","title":"Palbociclib with Letrozole in Postmenopausal Women with ER+/HER2− Advanced Breast Cancer: Hematologic Safety Analysis of the Randomized PALOMA-2 Trial","year":2019,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Calgary; University of Alberta","funders":"Genentech; Pfizer","keywords":"Letrozole; Palbociclib; Medicine; Oncology; Internal medicine; Postmenopausal women; Randomized controlled trial; Breast cancer; Cancer; Gynecology; Tamoxifen; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00234526,0.0008851025,0.001456029,0.00036814,0.0002305206,0.0009441709,0.0006850747,0.00102747,0.004460609],"category_scores_gemma":[0.002528443,0.0003740105,0.001563709,0.0003987063,0.0005145484,0.0006684886,0.0003844256,0.002072213,0.0004398312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006839891,"about_ca_system_score_gemma":0.001089673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005938301,"about_ca_topic_score_gemma":0.001632829,"domain_scores_codex":[0.998934,0.0007505612,0.00005428851,0.0001040426,0.00009485355,0.00006223431],"domain_scores_gemma":[0.9992251,0.0002534795,0.0002540816,0.00005094744,0.00006423915,0.0001521716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9454441,0.002981177,0.002346808,0.001385669,0.002949998,0.00008186959,0.00004196246,0.0008672398,0.003980536,0.000238778,0.00236113,0.03732081],"study_design_scores_gemma":[0.9348662,0.05464932,0.004312522,0.0001018279,0.001930658,0.0001113993,0.00002771382,0.0007292224,0.0007452311,0.0003389392,0.002172457,0.00001442686],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602706,0.02424049,0.001139385,0.001806331,0.0004309026,0.00397395,0.00263492,0.00019145,0.005311972],"genre_scores_gemma":[0.9853219,0.005243612,0.0008664511,0.00140759,0.0004013648,0.003042973,0.001699862,0.00002356011,0.001992677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004460609,"threshold_uncertainty_score":0.0149222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006386544342530553,"score_gpt":0.2729757012801935,"score_spread":0.2665891569376629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}