{"id":"W2950878851","doi":"10.3389/fimmu.2019.00060","title":"Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Région Auvergne-Rhône-Alpes; Université Claude Bernard Lyon 1; Ministère des Affaires Sociales et de la Santé; Université Laval; Direction Générale de l’offre de Soins; Institut National de la Santé et de la Recherche Médicale","keywords":"Repurposing; Drug repositioning; Virus; In vivo; Oseltamivir; Context (archaeology); Ex vivo; Medicine; Influenza A virus; Pharmacology; Biology; Virology; Drug; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003055697,0.0008668962,0.001251817,0.0006575474,0.0002002338,0.0008354739,0.0005029454,0.0003351127,0.003255181],"category_scores_gemma":[0.0004255013,0.0002505221,0.001422916,0.0004059616,0.0001950451,0.0004175667,0.0003953077,0.0004718396,0.0007079118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003442953,"about_ca_system_score_gemma":0.0008123898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005261111,"about_ca_topic_score_gemma":0.001400802,"domain_scores_codex":[0.9998617,0.00002616696,0.000009701656,0.00003063922,0.00004758257,0.00002419752],"domain_scores_gemma":[0.9999192,0.00003061333,0.00001983775,0.000007677293,0.00001333135,0.00000938348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002667663,0.001004456,0.01517387,0.003349609,0.0007167317,0.001988636,0.0001044029,0.265807,0.3940125,0.01030864,0.005575002,0.2992916],"study_design_scores_gemma":[0.0008588575,0.006832726,0.01081734,0.0002855623,0.001898153,0.001623039,0.0002074162,0.7381794,0.1790224,0.009754307,0.05036911,0.0001515695],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8714124,0.01558213,0.09046396,0.0007198409,0.0001517677,0.00086741,0.004334365,0.001359283,0.01510887],"genre_scores_gemma":[0.8966438,0.009665644,0.07906795,0.0004990937,0.00007978504,0.000714067,0.008353421,0.0001861554,0.004790153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003255181,"threshold_uncertainty_score":0.01088971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03602667411534761,"score_gpt":0.3648677190270596,"score_spread":0.328841044911712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}