{"id":"W2950878851","doi":"10.3389/fimmu.2019.00060","title":"Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Région Auvergne-Rhône-Alpes; Université Claude Bernard Lyon 1; Ministère des Affaires Sociales et de la Santé; Université Laval; Direction Générale de l’offre de Soins; Institut National de la Santé et de la Recherche Médicale","keywords":"Repurposing; Drug repositioning; Virus; In vivo; Oseltamivir; Context (archaeology); Ex vivo; Medicine; Influenza A virus; Pharmacology; Biology; Virology; Drug; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005891639,0.0002067441,0.0007938454,0.0004951895,0.00005847825,0.000008963554,0.0001561207,0.000525178,0.0000928403],"category_scores_gemma":[0.001156888,0.0001831464,0.0001756353,0.0003227867,0.0003990447,0.0001576131,0.0002783973,0.0009154867,0.00006101616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967792,"about_ca_system_score_gemma":0.0001845954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008847964,"about_ca_topic_score_gemma":0.000006432907,"domain_scores_codex":[0.9977335,0.0002201934,0.0008505366,0.0004668798,0.0003270707,0.0004018354],"domain_scores_gemma":[0.998643,0.0002616467,0.000283419,0.0005622629,0.0001891203,0.00006049183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002215874,0.0002647579,0.6156026,0.00004170142,0.00029911,0.000009472118,0.000921378,0.00005271449,0.3688997,0.00002609884,0.002585153,0.009081499],"study_design_scores_gemma":[0.01063011,0.001416903,0.5364568,0.0007879073,0.00008796711,0.000009679215,0.0009793525,0.0001657918,0.399063,0.0007429805,0.04929623,0.0003632949],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981499,0.0130712,0.000384073,0.00006780231,0.002828255,0.0006390504,0.00001085192,0.00005294023,0.001446822],"genre_scores_gemma":[0.9805533,0.002032256,0.01610558,0.0006483864,0.00026441,0.00004249808,0.00003285276,0.00004541398,0.0002753324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07914576,"threshold_uncertainty_score":0.7468495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03602667411534761,"score_gpt":0.3648677190270596,"score_spread":0.328841044911712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}