{"id":"W2950921432","doi":"10.1182/blood-2018-99-114275","title":"A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Gemtuzumab ozogamicin; Stem cell; Leukemia; Medicine; Calicheamicin; Oncology; Immunology; Sensitization; Internal medicine; Myeloid leukemia; Cancer research; CD33; Biology; CD34; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491922,0.0003300017,0.0004306078,0.0004248832,0.0001204818,0.0005813251,0.0002055532,0.0003174231,0.001547417],"category_scores_gemma":[0.001073979,0.0001132564,0.0003884803,0.0002967505,0.0001247748,0.0002472336,0.0003614644,0.0005180871,0.0003405292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004171775,"about_ca_system_score_gemma":0.0002950463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309404,"about_ca_topic_score_gemma":0.001316761,"domain_scores_codex":[0.9998673,0.00004802473,0.000008207535,0.00003016725,0.00002166534,0.00002454517],"domain_scores_gemma":[0.9997557,0.00009734662,0.00006976224,0.00001827955,0.00002022537,0.00003876053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003546852,0.000380926,0.801416,0.00006878054,0.00035348,0.0002067315,0.0000723773,0.1121068,0.02896836,0.001222326,0.001669696,0.04998761],"study_design_scores_gemma":[0.0001575192,0.001247086,0.3585801,0.00002367523,0.0003126567,0.0003315366,0.0001064095,0.6217602,0.01136264,0.002776683,0.003301962,0.00003937637],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943877,0.0002377918,0.004251993,0.0001282158,0.000008208611,0.00001970387,0.0004168568,0.00005646845,0.0004931454],"genre_scores_gemma":[0.9979655,0.00004614098,0.001295577,0.00002044321,0.000006575192,0.00001114015,0.0004461023,0.000006646192,0.0002020081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547417,"threshold_uncertainty_score":0.005176663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03047327767904125,"score_gpt":0.2925056112534201,"score_spread":0.2620323335743789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}