{"id":"W2950932397","doi":"10.1039/c9md00146h","title":"On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome","year":2019,"lang":"en","type":"review","venue":"MedChemComm","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Secretion; Virulence; Computational biology; Biology; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007979766,0.0003673539,0.0006952003,0.00005760304,0.0002315722,0.00003177346,0.0008427547,0.0002410738,0.00001165374],"category_scores_gemma":[0.0002518139,0.0001881346,0.0001783458,0.0003464808,0.00009519255,0.000001614971,0.0003710098,0.0003984107,0.0000217967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032603,"about_ca_system_score_gemma":0.0006046906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001085013,"about_ca_topic_score_gemma":0.00001176486,"domain_scores_codex":[0.9979551,0.0004235306,0.000477859,0.0003988164,0.0004159937,0.0003286787],"domain_scores_gemma":[0.9984314,0.0002007632,0.0003246859,0.0007903975,0.0002059202,0.00004681155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002689304,0.000224172,0.0001406966,0.03577818,0.003363212,0.000005817025,0.001455467,0.0002372475,0.1118554,0.0008814012,0.004313571,0.8414758],"study_design_scores_gemma":[0.0001641513,0.0002356098,0.00003841518,0.003193054,0.0001738643,0.000003119188,0.000205461,0.00006375611,0.0135007,0.000003337878,0.9820475,0.0003710627],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02405122,0.9730318,0.0002906148,0.0001214445,0.0003729187,0.001734797,0.00003624948,0.00001814019,0.0003428793],"genre_scores_gemma":[0.1539384,0.8433093,0.0009387423,0.0005101903,0.0003241832,0.0002881002,0.0002824387,0.0001228897,0.0002857823],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9777339,"threshold_uncertainty_score":0.7671908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04958219378180303,"score_gpt":0.3341008300021729,"score_spread":0.2845186362203699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}