{"id":"W2950953435","doi":"10.1242/dmm.038539","title":"Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance","year":2019,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Fondation pour la Recherche Médicale; Seventh Framework Programme; Wellcome Trust","keywords":"Expression quantitative trait loci; Biology; Quantitative trait locus; Genetics; Phenotype; Gene; Insulin resistance; Context (archaeology); Transcriptome; Genetic architecture; Allele; Gene expression; Diabetes mellitus; Endocrinology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002568465,0.0001551037,0.0002489737,0.0007438906,0.00012721,0.0002308617,0.0001196233,0.0001497694,0.000757053],"category_scores_gemma":[0.0002826025,0.0001580505,0.0002427561,0.0003044623,0.0002267967,0.0001084629,0.0002650796,0.0002861234,0.00008243346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001469342,"about_ca_system_score_gemma":0.0001228901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005310982,"about_ca_topic_score_gemma":0.0007424138,"domain_scores_codex":[0.9997274,0.00004394864,0.0000161989,0.0001026017,0.00006155676,0.00004814011],"domain_scores_gemma":[0.9996573,0.00005491755,0.0001516622,0.00004292667,0.00002963803,0.00006355625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000360171,0.00002588236,0.01362944,0.0000211709,0.00004563342,0.00008155996,0.00004691207,0.00009219849,0.9843943,0.0001034801,0.0000196185,0.00117961],"study_design_scores_gemma":[0.00001912323,0.0002995073,0.9353316,0.000008106766,0.00009558098,0.0006432351,0.0001097462,0.0008602846,0.06196186,0.0002529143,0.0004013547,0.00001666196],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979658,0.0001693869,0.001382488,0.00001785061,0.000002914663,0.000003391353,0.000275605,0.00001780314,0.0001648324],"genre_scores_gemma":[0.998152,0.0001199697,0.0008544247,0.00002808272,0.00000273003,0.00001278144,0.0004584176,0.00001713326,0.0003544485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000757053,"threshold_uncertainty_score":0.002532542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629784839030486,"score_gpt":0.2157352108970524,"score_spread":0.1994373625067475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}