{"id":"W2950955282","doi":"10.1186/s12896-018-0458-6","title":"Expression of novel fusion antiviral proteins ricin a chain-pokeweed antiviral proteins (RTA-PAPs) in Escherichia coli and their inhibition of protein synthesis and of hepatitis B virus in vitro","year":2018,"lang":"en","type":"article","venue":"BMC Biotechnology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Mental Health & Substance Use Services","funders":"","keywords":"Ricin; Biology; Fusion protein; Antiviral protein; Molecular biology; Ribosome-inactivating protein; Inclusion bodies; Escherichia coli; Biochemistry; Hepatitis B virus; Virus; Recombinant DNA; Virology; RNA; Toxin; Ribosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426628,0.0003968131,0.0002743605,0.0001771577,0.0001151184,0.0002788943,0.0002102815,0.0002956029,0.0004252635],"category_scores_gemma":[0.0001465068,0.0001267051,0.0003739163,0.000227318,0.0001747122,0.0002015949,0.0001991425,0.0005028074,0.0002638874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000334205,"about_ca_system_score_gemma":0.0001660652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002914653,"about_ca_topic_score_gemma":0.000339612,"domain_scores_codex":[0.9998116,0.00003497926,0.00002254888,0.00003829689,0.00006352195,0.00002915809],"domain_scores_gemma":[0.9998766,0.00002176561,0.00005050815,0.0000171857,0.00001970493,0.00001421761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003083003,0.00002119453,0.00008958965,0.00003080006,0.000004205076,0.00002734423,0.000008197482,0.0001004186,0.9991905,0.0000408541,0.00001304288,0.0004430442],"study_design_scores_gemma":[0.000004748433,0.0001268974,0.0007672017,0.000003568595,0.00001199144,0.0001549816,0.00001026996,0.0009373061,0.9965578,0.00001451934,0.001407811,0.000002827701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890079,0.001048934,0.008655868,0.00009472858,0.00002083786,0.0000532447,0.0004402309,0.0000646304,0.0006135475],"genre_scores_gemma":[0.9795063,0.0009494437,0.01466271,0.00003878185,0.00001002048,0.00005708681,0.001936057,0.00003334678,0.00280622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004252635,"threshold_uncertainty_score":0.002424836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053006137729426,"score_gpt":0.2108432810455591,"score_spread":0.2003132196682648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}