{"id":"W2950980122","doi":"10.1136/annrheumdis-2019-eular.2680","title":"FRI0512 RETRO-INVERSO TAT-BECLIN-1 INDUCES SYNOVIAL FIBROSIS AND DOES NOT PROTECT CARTILAGE FROM DEGENERATION IN A MOUSE MODEL OF OA","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Autophagy; Medicine; Osteoarthritis; Fibrosis; Synovitis; Cartilage; Inflammation; PI3K/AKT/mTOR pathway; Myofibroblast; Pathology; Cancer research; Arthritis; Internal medicine; Cell biology; Chemistry; Apoptosis; Signal transduction; Biology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000427849,0.001021592,0.0006315816,0.001760254,0.0005382189,0.0006609377,0.0007391597,0.001988235,0.004360119],"category_scores_gemma":[0.00027049,0.0006154622,0.0008899728,0.000511019,0.001192355,0.0008088883,0.0003331755,0.002633387,0.001270513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006786272,"about_ca_system_score_gemma":0.0004490622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704945,"about_ca_topic_score_gemma":0.003170085,"domain_scores_codex":[0.9991059,0.0001200324,0.0001142398,0.0002339509,0.0002298209,0.0001960793],"domain_scores_gemma":[0.9991224,0.00009655311,0.0003392818,0.000101533,0.00004406095,0.000296046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005258158,0.0001185249,0.0001204921,0.00004806054,0.00001615925,0.0001729357,0.00002427233,0.00006677314,0.9979797,0.0002319301,0.0000948368,0.0006004466],"study_design_scores_gemma":[0.0001567601,0.001010043,0.00352238,0.00002027696,0.00006985926,0.001138791,0.0001450264,0.00136889,0.9881338,0.0001560623,0.004253426,0.00002456457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876738,0.002434608,0.003897019,0.0007862021,0.0004123537,0.00007406087,0.002000327,0.0005252205,0.002196421],"genre_scores_gemma":[0.9788245,0.001123601,0.00351271,0.0003049638,0.00006400666,0.000146589,0.00135264,0.000187169,0.01448385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004360119,"threshold_uncertainty_score":0.01458603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762156535013427,"score_gpt":0.2557597040316342,"score_spread":0.2281381386814999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}