{"id":"W2950980129","doi":"10.1007/s12250-019-00121-4","title":"Construction of a One-Vector Multiplex CRISPR/Cas9 Editing System to Inhibit Nucleopolyhedrovirus Replication in Silkworms","year":2019,"lang":"en","type":"article","venue":"Virologica Sinica","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"CRISPR; Cas9; Genome editing; Biology; Subgenomic mRNA; Multiplex; Gene; CRISPR interference; Guide RNA; Computational biology; Genome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005019555,0.0004773581,0.0006324241,0.0004913189,0.0003977665,0.0005588388,0.0007435913,0.0005583299,0.001177327],"category_scores_gemma":[0.0002113513,0.0004756434,0.0005101415,0.0002388228,0.0002803018,0.0003089822,0.0005426999,0.000965135,0.0006322836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005264533,"about_ca_system_score_gemma":0.0003765359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042641,"about_ca_topic_score_gemma":0.002018024,"domain_scores_codex":[0.9995484,0.000041618,0.00006378813,0.0001427815,0.0001442714,0.00005915004],"domain_scores_gemma":[0.9998021,0.00003217319,0.00006608677,0.0000335176,0.00001711932,0.00004907959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003435323,0.00002151918,0.000115423,0.00003376121,0.000008533054,0.00003835601,0.0000210455,0.00009864783,0.9976881,0.0002255026,0.00005277011,0.001661974],"study_design_scores_gemma":[0.00002677161,0.0001328269,0.001758234,0.00000758199,0.00004412187,0.0001876404,0.00002133495,0.003167195,0.9893069,0.00006394197,0.005263833,0.00001963182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8757548,0.001217507,0.1140258,0.0002209509,0.0002114635,0.0007082935,0.002158047,0.001268002,0.004435139],"genre_scores_gemma":[0.9259201,0.0005957676,0.05876599,0.00008100407,0.00001904587,0.0003030117,0.002233183,0.000143452,0.01193848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177327,"threshold_uncertainty_score":0.003938615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053933631623322,"score_gpt":0.2863471512471353,"score_spread":0.2758078149309021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}