{"id":"W2950988732","doi":"10.1093/nar/gkz514","title":"A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Université Laval","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Canadian Institutes of Health Research; Fanconi Anemia Research Fund","keywords":"FANCD2; Biology; FANCA; Homologous recombination; Fanconi anemia; Genetics; Phenotype; DNA repair; Mutation; Meiosis; Epistasis; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000755568,0.0001625538,0.0002105207,0.00008671812,0.0002291736,0.00007130709,0.0002047536,0.0002190653,0.00002648833],"category_scores_gemma":[0.0002138695,0.0001533673,0.00006392777,0.0000989167,0.0001550763,0.00001072011,0.0004127378,0.000225205,0.00003564474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002889916,"about_ca_system_score_gemma":0.00007225537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001924781,"about_ca_topic_score_gemma":0.00004282261,"domain_scores_codex":[0.9983681,0.00009917647,0.0001892358,0.0005656827,0.0002791836,0.0004985507],"domain_scores_gemma":[0.9989428,0.00006497785,0.00003862192,0.0005676301,0.0002023576,0.0001836075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002314978,0.00006418653,0.00484658,0.0001179296,0.00003887717,9.037408e-7,0.00009359021,0.00002005783,0.9834247,0.0008244286,0.005462248,0.004875056],"study_design_scores_gemma":[0.008852077,0.007601839,0.01553816,0.0001839142,0.0001077605,0.0001039267,0.001897077,0.07927199,0.7097762,0.01529058,0.159376,0.002000562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926946,0.0003649124,0.003133499,0.0001930888,0.00006720645,0.0008408211,0.0001558521,0.00002942543,0.002520627],"genre_scores_gemma":[0.9744466,0.00009615301,0.002085099,0.00009667274,0.000114288,0.0001450334,0.00008362818,0.00005176139,0.02288079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2736485,"threshold_uncertainty_score":0.6254138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03470216080561837,"score_gpt":0.3313673039362103,"score_spread":0.2966651431305919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}