{"id":"W2950992316","doi":"10.1101/296707","title":"New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; European Commission; North West Cancer Research; Pfizer","keywords":"Sulfation; Biochemistry; Rottlerin; Tyrosine kinase; Receptor tyrosine kinase; Chemistry; Tyrosine; Biology; Proteome; Protein kinase A; Kinase; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007351208,0.001140966,0.0006605941,0.001783726,0.0002760103,0.0005551465,0.0004842055,0.0007113235,0.003648693],"category_scores_gemma":[0.0004852044,0.0004477414,0.0005621955,0.0007206179,0.0003413204,0.0005337697,0.0004278612,0.001037752,0.001023881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004405198,"about_ca_system_score_gemma":0.0002185825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005128195,"about_ca_topic_score_gemma":0.001118427,"domain_scores_codex":[0.9993256,0.0001761867,0.00004777617,0.00009388134,0.0002750517,0.00008143214],"domain_scores_gemma":[0.9996001,0.0001166751,0.0000988203,0.00003032202,0.00009322025,0.0000609466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001401636,0.00004525471,0.0003569119,0.0001058871,0.00001681911,0.0000253538,0.00001500147,0.0001836743,0.9945331,0.00009524816,0.00005525673,0.004427392],"study_design_scores_gemma":[0.000021766,0.0005508944,0.003038983,0.000009274283,0.00004140344,0.0001947248,0.00002264815,0.002913958,0.9904777,0.00007758859,0.002638746,0.00001231003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8271949,0.01345618,0.1428948,0.0004159698,0.0002242967,0.0007113279,0.003950505,0.00168532,0.009466801],"genre_scores_gemma":[0.8518566,0.007710737,0.120395,0.0001464343,0.0000718549,0.0009745002,0.003368767,0.0001678295,0.01530822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003648693,"threshold_uncertainty_score":0.01220614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0296382369649286,"score_gpt":0.2662038123667613,"score_spread":0.2365655754018327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}