{"id":"W2951010431","doi":"10.1101/284141","title":"Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer’s Disease: Relationship to Neuroimaging and CSF Biomarkers","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Neuroimaging; Neurodegeneration; Neuroinflammation; Medicine; Alzheimer's disease; Dementia; Disease; Internal medicine; Alzheimer's Disease Neuroimaging Initiative; Endocrinology; Pathology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004465297,0.0004603566,0.0004705164,0.001092262,0.0003283535,0.0006152411,0.0001757394,0.000406917,0.001626339],"category_scores_gemma":[0.001397474,0.0001458113,0.0002058786,0.0007019155,0.0002541523,0.000275303,0.000364222,0.0003063561,0.0002852156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340068,"about_ca_system_score_gemma":0.0002381018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002916022,"about_ca_topic_score_gemma":0.003413009,"domain_scores_codex":[0.9998444,0.00003330356,0.00002806721,0.00004222232,0.00002855257,0.00002335443],"domain_scores_gemma":[0.9992589,0.00009072239,0.0003463024,0.0000622928,0.0001248111,0.0001168781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00171879,0.0001089864,0.9828995,0.00004523611,0.0002153335,0.000230622,0.00005608248,0.00005911436,0.005185338,0.00002422162,0.0002031755,0.009253598],"study_design_scores_gemma":[0.0000120222,0.0001445588,0.9981237,0.000009352599,0.00005568793,0.0004866136,0.00006518755,0.0001360738,0.0007047688,0.0001029115,0.0001551462,0.0000039319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979612,0.0009441631,0.0001334196,0.00008566954,0.000009399088,0.000007127009,0.0003624323,0.000007354472,0.0004892937],"genre_scores_gemma":[0.9990283,0.0002077968,0.0002376148,0.00003128213,0.00001398945,0.000006494885,0.0002322648,0.000001581973,0.000240804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002916022,"threshold_uncertainty_score":0.005798101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03887692612901662,"score_gpt":0.30060317123345,"score_spread":0.2617262451044334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}