{"id":"W2951013116","doi":"10.1101/383828","title":"A macrophage-based screen identifies antibacterial compounds selective for intracellular <i>Salmonella</i> Typhimurium","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Intracellular; Innate immune system; Intracellular parasite; Macrophage; Salmonella; Microbiology; Biology; Bacterial outer membrane; In vivo; Cytoplasm; In vitro; Immune system; Cell biology; Bacteria; Biochemistry; Immunology; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002402724,0.0004801029,0.0004668089,0.0003705566,0.0001756456,0.0002901091,0.0002588274,0.0003483084,0.001476802],"category_scores_gemma":[0.000160983,0.0001629588,0.0002909368,0.0001831997,0.0001901876,0.0001307154,0.0002771438,0.0003257413,0.0004101678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443681,"about_ca_system_score_gemma":0.0003124799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008458989,"about_ca_topic_score_gemma":0.001495607,"domain_scores_codex":[0.9998454,0.00003755317,0.0000118363,0.00003324882,0.0000382383,0.0000337511],"domain_scores_gemma":[0.9998887,0.00002800142,0.00002056391,0.00001218863,0.00002402558,0.00002638485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559953,0.00006049983,0.0003000644,0.00003844583,0.000005238018,0.00003332119,0.00000942908,0.00007521072,0.9976621,0.00002710735,0.00007710892,0.001555447],"study_design_scores_gemma":[0.00004758902,0.002345475,0.002746429,0.000009631843,0.0000278189,0.0002859278,0.00003030859,0.000499453,0.9920108,0.00002447669,0.001965254,0.000006978371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927748,0.0012867,0.002234648,0.0003150016,0.00002899324,0.0001201741,0.0009797578,0.0001459833,0.002113829],"genre_scores_gemma":[0.9889202,0.001130623,0.005040095,0.0001776274,0.00001568522,0.00007435714,0.001042983,0.00004357412,0.003554887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476802,"threshold_uncertainty_score":0.004940391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01918558901215503,"score_gpt":0.2235116944219362,"score_spread":0.2043261054097812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}