{"id":"W2951021399","doi":"10.1126/sciadv.aav9946","title":"Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Directorate-General for Research and Innovation; Novo Nordisk Fonden; Lundbeckfonden; Canadian Institutes of Health Research; Aase og Ejnar Danielsens Fond; Carlsbergfondet; Danmarks Grundforskningsfond; Simon Fougner Hartmanns Familiefond; Dagmar Marshalls Fond","keywords":"Neurotensin; Neuropathic pain; Peripheral; Neuroscience; Medicine; Pain control; Signal transduction; Biology; Internal medicine; Neuropeptide; Cell biology; Anesthesia; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408053,0.0002802457,0.0002759274,0.000159011,0.0001306574,0.0003854239,0.0002407682,0.0003030482,0.0009831276],"category_scores_gemma":[0.00007272953,0.0001099048,0.0001728131,0.00008578483,0.0002696292,0.00029332,0.0002774238,0.0005755032,0.0002871537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003580238,"about_ca_system_score_gemma":0.0002782086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006320339,"about_ca_topic_score_gemma":0.001489774,"domain_scores_codex":[0.999878,0.00001875625,0.00001027202,0.00001934653,0.00003459587,0.00003898472],"domain_scores_gemma":[0.9999433,0.000005344808,0.00001725348,0.000003474545,0.000008146953,0.00002254067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002817353,0.00001938046,0.000153518,0.0000987266,0.000008344769,0.00005543471,0.00001663203,0.00009172304,0.9955038,0.0005745525,0.0001147955,0.003081356],"study_design_scores_gemma":[0.00008332473,0.0005689056,0.005297845,0.00001905549,0.00003930153,0.000574694,0.00006246147,0.002377168,0.9785842,0.0002683718,0.01211071,0.00001395303],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771822,0.007391043,0.008741962,0.0005603508,0.00014218,0.00007924079,0.0003467971,0.0002229457,0.00533319],"genre_scores_gemma":[0.990368,0.002380649,0.003616476,0.0001946609,0.00001893813,0.00003106452,0.0001812672,0.00001921894,0.003189769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009831276,"threshold_uncertainty_score":0.003288865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008550637058032603,"score_gpt":0.2664114873299933,"score_spread":0.2578608502719607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}