{"id":"W2951021399","doi":"10.1126/sciadv.aav9946","title":"Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Directorate-General for Research and Innovation; Novo Nordisk Fonden; Lundbeckfonden; Canadian Institutes of Health Research; Aase og Ejnar Danielsens Fond; Carlsbergfondet; Danmarks Grundforskningsfond; Simon Fougner Hartmanns Familiefond; Dagmar Marshalls Fond","keywords":"Neurotensin; Neuropathic pain; Peripheral; Neuroscience; Medicine; Pain control; Signal transduction; Biology; Internal medicine; Neuropeptide; Cell biology; Anesthesia; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001316622,0.0001132067,0.0001904366,0.00008442027,0.0001403992,0.00004694293,0.00009146498,0.00001764072,0.00003423504],"category_scores_gemma":[0.0005224246,0.00008347938,0.00002658093,0.0002943773,0.0001433092,0.0002669594,0.0000280465,0.00007860315,0.00003883799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002219901,"about_ca_system_score_gemma":0.0000723314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008854264,"about_ca_topic_score_gemma":0.000002802698,"domain_scores_codex":[0.9987563,0.00008583201,0.0001294993,0.0004046241,0.0003123575,0.0003113858],"domain_scores_gemma":[0.9993814,0.0001259491,0.0000410406,0.0001781169,0.00008024039,0.0001933021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000882346,0.00004037221,0.05097517,0.00002470497,0.00000428741,0.00005911447,0.0001685377,0.0003167711,0.8902873,0.0001552154,0.000003416784,0.05787689],"study_design_scores_gemma":[0.01159555,0.01200838,0.2850345,0.001149902,0.0002110022,0.0004021078,0.003067191,0.09682859,0.5673962,0.007523643,0.01320788,0.001575106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946235,0.000606904,0.00288258,0.00105117,0.0001991212,0.0004286552,0.000001722705,0.00004278052,0.0001635552],"genre_scores_gemma":[0.9930636,0.00001439904,0.002890129,0.003721467,0.00003573038,0.000009777848,5.025453e-7,0.000008896076,0.0002555108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3228911,"threshold_uncertainty_score":0.340419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008550637058032603,"score_gpt":0.2664114873299933,"score_spread":0.2578608502719607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}