{"id":"W2951075204","doi":"10.1021/jo801190m","title":"Enantio- and Stereospecific Syntheses of 15(<i>R</i>)-Me-PGD<sub>2</sub>, A Potent and Selective DP<sub>2</sub>−Receptor Agonist","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute","keywords":"Stereospecificity; Stereocenter; Synthon; Stereochemistry; Enantioselective synthesis; Chemistry; Agonist; Prostanoid; Olefin metathesis; Ring (chemistry); Salt metathesis reaction; Prostaglandin; Enantiomer; Metathesis; Receptor; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002645358,0.0006232481,0.0004876507,0.0003030733,0.0002647629,0.0003128916,0.0004133634,0.0002712536,0.002414626],"category_scores_gemma":[0.0002225279,0.0003088205,0.0003455232,0.0003218162,0.0002381288,0.0003314277,0.0005186101,0.0005066767,0.001411044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352331,"about_ca_system_score_gemma":0.000846842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005339366,"about_ca_topic_score_gemma":0.0009089668,"domain_scores_codex":[0.9998205,0.00002650473,0.0000230332,0.00003148974,0.00004505495,0.00005344349],"domain_scores_gemma":[0.9999225,0.000008864833,0.0000155062,0.00001505585,0.00001369885,0.00002439512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000264895,0.00009375894,0.0001771836,0.0002681318,0.00003120695,0.0005531089,0.0001518664,0.001236162,0.9710231,0.002790435,0.0005375516,0.02287242],"study_design_scores_gemma":[0.00006319914,0.000403428,0.0004187807,0.000009817499,0.0000425019,0.0006643647,0.00003411878,0.000407199,0.9813798,0.0003713573,0.01618174,0.00002374101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7830402,0.01230504,0.1475718,0.0005777352,0.0004369555,0.0009745566,0.006433132,0.0008846868,0.04777591],"genre_scores_gemma":[0.9161083,0.006640114,0.05876698,0.0002122288,0.00007499717,0.0003457821,0.002752696,0.0001866002,0.01491234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002414626,"threshold_uncertainty_score":0.008077681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383217178545131,"score_gpt":0.217418632733665,"score_spread":0.2035864609482137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}