{"id":"W2951075204","doi":"10.1021/jo801190m","title":"Enantio- and Stereospecific Syntheses of 15(<i>R</i>)-Me-PGD<sub>2</sub>, A Potent and Selective DP<sub>2</sub>−Receptor Agonist","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute","keywords":"Stereospecificity; Stereocenter; Synthon; Stereochemistry; Enantioselective synthesis; Chemistry; Agonist; Prostanoid; Olefin metathesis; Ring (chemistry); Salt metathesis reaction; Prostaglandin; Enantiomer; Metathesis; Receptor; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001093459,0.000656723,0.001079109,0.00005841296,0.0003758965,0.00006604852,0.0007890155,0.0004292782,0.000729279],"category_scores_gemma":[0.001533184,0.0005251991,0.0002720309,0.0003936612,0.001058577,0.0001769715,0.000368329,0.00116631,0.00001149481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003132962,"about_ca_system_score_gemma":0.0005095851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005005251,"about_ca_topic_score_gemma":0.000002124357,"domain_scores_codex":[0.9964858,0.0001381863,0.001346515,0.0005337403,0.0008660484,0.0006297646],"domain_scores_gemma":[0.9955067,0.001269978,0.001490579,0.0008381538,0.0004683369,0.0004262394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003370266,0.000256117,0.0008317169,0.0005207022,0.0004166899,0.0000599895,0.001216223,0.000001291348,0.991218,0.000001295704,0.0007537378,0.004387163],"study_design_scores_gemma":[0.001183916,0.00006496575,0.0004683718,0.0004729871,0.000398827,0.009598982,0.001877807,0.00001281579,0.9849471,0.0001048058,0.0003531573,0.0005162859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941692,0.003325348,0.0002470109,0.0003992293,0.000123655,0.0001096837,0.00006551295,0.0000558099,0.00150452],"genre_scores_gemma":[0.9929588,0.00546016,0.0005918416,0.00003648243,0.0006508366,0.000003922659,0.000006052191,0.0001309868,0.0001609072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009538992,"threshold_uncertainty_score":0.99972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383217178545131,"score_gpt":0.217418632733665,"score_spread":0.2035864609482137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}