{"id":"W2951075811","doi":"10.1097/01.hs9.0000562932.11356.53","title":"PS1162 COMBINATION THERAPY TO PREVENT IBRUTINIB WITHDRAWAL: CONTINUED IBRUTINIB WITH THE ADDITION OF VENETOCLAX AT TIME OF PROGRESSION IN IBRUTINIB‐TREATED PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Ibrutinib; Venetoclax; Medicine; Internal medicine; Oncology; Chronic lymphocytic leukemia; Neutropenia; Discontinuation; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004282905,0.000425869,0.0008512097,0.0001554793,0.00008096315,0.00002058954,0.0003205396,0.0002265566,0.001308733],"category_scores_gemma":[0.00007031392,0.0002567763,0.0001128295,0.001000359,0.0002850175,0.0001558105,0.0001465639,0.0002624647,0.000154873],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03266465,"about_ca_system_score_gemma":0.01109978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007278146,"about_ca_topic_score_gemma":0.0003143303,"domain_scores_codex":[0.996413,0.0002209824,0.0007030474,0.000647135,0.001362695,0.0006531274],"domain_scores_gemma":[0.997402,0.0002893012,0.0005793669,0.0009899612,0.000540386,0.0001989745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1940921,0.007880125,0.49145,0.01097211,0.003891773,0.0004768057,0.01948343,0.02463412,0.1407061,0.000780383,0.03328279,0.07235025],"study_design_scores_gemma":[0.2580231,0.03269694,0.2485854,0.0145177,0.0003747323,0.0001835928,0.0006567771,0.03684725,0.4007275,0.00004245664,0.005891537,0.001453069],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920453,0.0003970232,0.000007804001,0.0001104278,0.00004155187,0.005640747,0.00004323461,0.00007134273,0.001642591],"genre_scores_gemma":[0.9952617,0.00003732021,0.000177425,0.00007908132,0.00004221285,0.0002783653,0.0003944371,0.0001012867,0.003628123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2600214,"threshold_uncertainty_score":0.9999884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005794280930207838,"score_gpt":0.2487847723173081,"score_spread":0.2429904913871003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}