{"id":"W2951075811","doi":"10.1097/01.hs9.0000562932.11356.53","title":"PS1162 COMBINATION THERAPY TO PREVENT IBRUTINIB WITHDRAWAL: CONTINUED IBRUTINIB WITH THE ADDITION OF VENETOCLAX AT TIME OF PROGRESSION IN IBRUTINIB‐TREATED PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Ibrutinib; Venetoclax; Medicine; Internal medicine; Oncology; Chronic lymphocytic leukemia; Neutropenia; Discontinuation; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004606151,0.0002628198,0.0005422325,0.0004558794,0.0003652037,0.0004863998,0.0002424893,0.0002263564,0.001787898],"category_scores_gemma":[0.0006981476,0.0001276319,0.0003034562,0.0005995501,0.0002060424,0.0002833369,0.0002364774,0.000478635,0.0003332251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005738162,"about_ca_system_score_gemma":0.0007412339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009702825,"about_ca_topic_score_gemma":0.002665987,"domain_scores_codex":[0.9997547,0.00006005221,0.00003048134,0.00005561066,0.00006022151,0.00003885717],"domain_scores_gemma":[0.9996207,0.00006835425,0.0001593202,0.00002158489,0.00003384349,0.00009618199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01797632,0.0009259835,0.6776865,0.0005358571,0.000251166,0.002864753,0.0003777755,0.0011582,0.03416515,0.0001785266,0.004434705,0.2594451],"study_design_scores_gemma":[0.002402426,0.02171767,0.9371657,0.000178777,0.0005259833,0.01100946,0.0001876911,0.002153934,0.009442781,0.0002104424,0.0149765,0.00002867919],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922547,0.003749956,0.0004361663,0.000143821,0.00002049667,0.0001012045,0.0003051321,0.00005299883,0.002935543],"genre_scores_gemma":[0.9973009,0.0008232802,0.0007171518,0.0001182639,0.00003471167,0.00004990431,0.0005091686,0.000006988234,0.0004396918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787898,"threshold_uncertainty_score":0.005981147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005794280930207838,"score_gpt":0.2487847723173081,"score_spread":0.2429904913871003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}