{"id":"W2951090524","doi":"10.1097/01.hs9.0000564792.15111.43","title":"S1636 FRACTIONATED DOSING OF ARI‐0001 CELLS (A3B1:CD8:4–1BB:CD3Z CAR19) AND EARLY TOCILIZUMAB ADMINISTRATION MAY REDUCE THE INCIDENCE OF SEVERE CYTOKINE RELEASE SYNDROME IN PATIENTS WITH CD19+ MALIGNANCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Apheresis Group","funders":"","keywords":"Medicine; Cytokine release syndrome; Cyclophosphamide; Fludarabine; Internal medicine; Cohort; Cytokine; CD8; Toxicity; Immunology; Dosing; Gastroenterology; Immune system; Cancer; Chemotherapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002712958,0.0001999682,0.000440263,0.00008562497,0.00004861876,0.00002171778,0.0001327992,0.0001402424,0.001127558],"category_scores_gemma":[0.00007522605,0.0001448443,0.00005937872,0.0004831656,0.0001814225,0.0002192366,0.00005720597,0.0003472798,0.00001362874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429939,"about_ca_system_score_gemma":0.0003145139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008856234,"about_ca_topic_score_gemma":0.0001447966,"domain_scores_codex":[0.9980628,0.0001055625,0.0004496116,0.0003470081,0.0007530439,0.0002820086],"domain_scores_gemma":[0.9985945,0.0001856662,0.0002596539,0.0005021874,0.0003573814,0.0001006522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006431208,0.0006340292,0.6388951,0.0009640692,0.0001522571,0.0001275321,0.001550948,0.0001339685,0.3469519,0.0001297646,0.0001951715,0.003834042],"study_design_scores_gemma":[0.005642319,0.002776654,0.855926,0.001303053,0.00007215733,0.0001807496,0.001148031,0.000101063,0.1321613,0.0000519296,0.0003880187,0.0002487291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967074,0.0002322458,0.000005290995,0.0002052917,0.00006048919,0.001165245,0.00002765487,0.00001907056,0.001577314],"genre_scores_gemma":[0.9956263,0.00004908215,0.0002560513,0.0000328462,0.00001875783,0.00002318983,0.00002379819,0.0000348028,0.003935135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2170309,"threshold_uncertainty_score":0.9997855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219629885850985,"score_gpt":0.2596954184873818,"score_spread":0.2474991196288719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}