{"id":"W2951090524","doi":"10.1097/01.hs9.0000564792.15111.43","title":"S1636 FRACTIONATED DOSING OF ARI‐0001 CELLS (A3B1:CD8:4–1BB:CD3Z CAR19) AND EARLY TOCILIZUMAB ADMINISTRATION MAY REDUCE THE INCIDENCE OF SEVERE CYTOKINE RELEASE SYNDROME IN PATIENTS WITH CD19+ MALIGNANCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Apheresis Group","funders":"","keywords":"Medicine; Cytokine release syndrome; Cyclophosphamide; Fludarabine; Internal medicine; Cohort; Cytokine; CD8; Toxicity; Immunology; Dosing; Gastroenterology; Immune system; Cancer; Chemotherapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171251,0.0001874564,0.0003599713,0.00009029985,0.00006663031,0.0001909577,0.0001851948,0.0001517616,0.002532375],"category_scores_gemma":[0.000192304,0.00005794648,0.0002103216,0.00007246494,0.0001330424,0.0001551094,0.0001022744,0.0004604834,0.0002909737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613732,"about_ca_system_score_gemma":0.0002062653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003521704,"about_ca_topic_score_gemma":0.0007942481,"domain_scores_codex":[0.9999659,0.000006462285,0.000002269813,0.000007778177,0.000005346041,0.00001223315],"domain_scores_gemma":[0.9998977,0.00001469435,0.00002351665,0.000009983419,0.000003847637,0.00005034729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05273275,0.01352527,0.035456,0.0002625931,0.0003586459,0.0003672737,0.0002660389,0.004160822,0.5343993,0.000468385,0.003102622,0.3549003],"study_design_scores_gemma":[0.0171571,0.317003,0.4106928,0.00008710782,0.0006902223,0.00325943,0.0002222938,0.0108694,0.2256279,0.0005789435,0.01375597,0.00005588948],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989859,0.0003076928,0.0002268534,0.00002773673,0.0000106817,0.00001957417,0.00004596809,0.0000331794,0.0003422843],"genre_scores_gemma":[0.9988922,0.0001016064,0.0005124568,0.00003182127,0.00001274744,0.00001603603,0.0001171456,0.000004235474,0.0003117454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002532375,"threshold_uncertainty_score":0.008471608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219629885850985,"score_gpt":0.2596954184873818,"score_spread":0.2474991196288719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}