{"id":"W2951099321","doi":"10.1016/j.bmcl.2009.09.011","title":"Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nevirapine; Chemistry; Click chemistry; Azide; Triazole; Pharmacokinetics; Combinatorial chemistry; Chemical synthesis; Human immunodeficiency virus (HIV); Pharmacology; Stereochemistry; Biochemistry; Organic chemistry; In vitro; Antiretroviral therapy; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002887911,0.0004206099,0.0006161604,0.0000379256,0.0001608099,0.00003042664,0.0007889844,0.0001623444,0.002450416],"category_scores_gemma":[0.0004854458,0.0004102743,0.0001510858,0.0006082486,0.00009184073,0.00003547007,0.0001012496,0.000401201,0.00004279152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009857188,"about_ca_system_score_gemma":0.00005519227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002495639,"about_ca_topic_score_gemma":4.232564e-7,"domain_scores_codex":[0.9972942,0.00002187366,0.0007464043,0.0007529354,0.0006550461,0.0005295665],"domain_scores_gemma":[0.998209,0.0001599415,0.0003090232,0.0008434652,0.00009517182,0.0003834087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000045004,0.0007914157,0.0003241818,0.0001434252,0.0001003184,0.0000155573,0.0003047431,0.00001244255,0.9892777,0.000002093611,0.006542409,0.002440674],"study_design_scores_gemma":[0.0006496508,0.00002022756,0.0008243585,0.0001233435,0.0002387898,0.00002750434,0.0006599217,0.00006364767,0.9940305,0.000001893514,0.002982891,0.0003772169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896172,0.0005932793,0.0000657405,0.007351364,0.00002746485,0.0002465807,0.000149455,0.0001388074,0.001810112],"genre_scores_gemma":[0.9980838,0.00001786812,0.0001285949,0.000873082,0.0004113651,0.00009167762,0.00007563897,0.00003688362,0.000281133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008466561,"threshold_uncertainty_score":0.9998349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161776453906129,"score_gpt":0.2492630021443681,"score_spread":0.2376452376053068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}