{"id":"W2951123340","doi":"10.1101/281956","title":"Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Biogen; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Bile acid; Cognitive decline; Neurodegeneration; Disease; Deoxycholic acid; Microbiome; Internal medicine; Medicine; Biology; Endocrinology; Dementia; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004831227,0.0004366729,0.0005008469,0.001226411,0.0003305351,0.0009181809,0.0002561932,0.0004815866,0.002152399],"category_scores_gemma":[0.001134583,0.0001846097,0.0005316662,0.001253207,0.0003198543,0.0003376768,0.0005562791,0.000454664,0.0002020134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863066,"about_ca_system_score_gemma":0.000199449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003058203,"about_ca_topic_score_gemma":0.002418248,"domain_scores_codex":[0.9997111,0.00008001486,0.00003616551,0.00008791744,0.00004493734,0.00003990799],"domain_scores_gemma":[0.9991452,0.0001201782,0.0004419539,0.00007127198,0.0001338417,0.000087557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004813439,0.00003874455,0.9863546,0.00006137505,0.000455161,0.0002832343,0.0000640896,0.00005074132,0.003460326,0.00007268366,0.0002711618,0.008406471],"study_design_scores_gemma":[0.00000611005,0.00006796894,0.9978772,0.00002373871,0.0001291223,0.0007014979,0.00007753796,0.0001710498,0.0003375655,0.0001990727,0.0004031182,0.000005842329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911503,0.006497035,0.0004692209,0.0003971112,0.00003816522,0.000005658624,0.0005860258,0.00002029301,0.0008363065],"genre_scores_gemma":[0.9976051,0.001085744,0.0005829367,0.00008576328,0.00006454525,0.000003813677,0.0002734234,0.000004956817,0.000293584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003058203,"threshold_uncertainty_score":0.007200539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636668472120431,"score_gpt":0.2546957518821741,"score_spread":0.2383290671609698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}